SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity
Joint Authors
Karstensen, John G.
Vilmann, Peter
Saftoiu, Adrian
Klausen, Pia
Coskun, Mehmet
Cowland, Jack Bernard
Riis, Lene Buhl
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Small mothers against decapentaplegic (SMAD)4 and SMAD7 are key regulatory components in the immunosuppressive transforming growth factor- (TGF-) β signaling pathway, which is defective in inflammatory bowel disease (IBD).
SMAD4 may play an important role in the pathogenesis of IBD as indicated in experimental models of colitis.
Aims.
To examine the ileal expression levels of SMAD4 and to correlate these with CD disease activity.
Methods.
The material comprised 29 CD patients (13 with active disease, 16 in remission) and 9 asymptomatic patients referred for ileocolonoscopy as part of an adenoma surveillance program serving as controls.
Patients were examined with ileocolonoscopy.
Corresponding ileal biopsies were obtained for histological analysis and assessment of SMAD4 and SMAD7 protein expression by immunohistochemistry (IHC).
Results.
The protein expression of SMAD4 was significantly downregulated in ileal tissue sections from CD patients as compared to healthy controls (p<0.001).
Further, luminal SMAD4 expression was inversely correlated with endoscopic (rs=−0.315; p=0.05) and histopathological activity (rs=−0.40; p=0.013).
Conclusions.
The SMAD4 epithelial protein level was markedly downregulated in CD patients and inversely correlated with disease activity.
This may contribute to defective mucosal TGF-β signaling in active IBD.
American Psychological Association (APA)
Klausen, Pia& Karstensen, John G.& Coskun, Mehmet& Saftoiu, Adrian& Vilmann, Peter& Cowland, Jack Bernard…[et al.]. 2018. SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165939
Modern Language Association (MLA)
Klausen, Pia…[et al.]. SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity. Gastroenterology Research and Practice No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1165939
American Medical Association (AMA)
Klausen, Pia& Karstensen, John G.& Coskun, Mehmet& Saftoiu, Adrian& Vilmann, Peter& Cowland, Jack Bernard…[et al.]. SMAD4 Protein Expression Is Downregulated in Ileal Epithelial Cells from Patients with Crohn’s Disease with Significant Inverse Correlation to Disease Activity. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1165939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165939