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Rectal Indomethacin Is Protective against Pancreatitis after Endoscopic Retrograde Cholangiopancreatography: Systematic Review and Meta-Analysis
المؤلفون المشاركون
Sun, Leimin
Si, Jianmin
He, Xing-kang
Ding, Yu-e
Zheng, Wenfang
Tang, Xia
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background and Aim.
Rectal indomethacin was reported to be effective for postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) prophylaxis.
However, the preventive effect of indomethacin for average-risk patients remains unclear.
Recently, some conflicting evidence was addressed by recent articles.
We aimed to determine the protective role of indomethacin in PEP based on the latest available literature.
Methods.
A systematic literature search was conducted using PubMed, Embase, Web of Science, and the Cochrane Library to identify related articles published before October 2016.
Studies that evaluated the administration of indomethacin in the prevention of PEP were included in the analysis.
We adopted a random-effects model to calculate the overall relative risk (RR) and 95% confidence interval (CI).
Results.
Ten trials from an initial search were finally included in the meta-analysis.
The administration of rectal indomethacin significantly reduced the incidence of PEP in consecutive ERCP population (RR, 0.63; 95% CI, 0.50–0.77).
There was no significant heterogeneity across included studies (I2=14.2%, P=0.31).
Further subgroup analyses also revealed that rectal indomethacin could protect the individuals at high and average risks and reduced severity of PEP.
Pre-ERCP administration of indomethacin seemed to be better than the post-ERCP given.
There was no evidence of significant publication bias.
Conclusions.
Rectal administration of indomethacin is an effective approach to prevent the incidence of PEP in both high- and average-risk populations undergoing ERCP.
However, more high-quality RCTs are needed to further investigate the optimal timing for the administration of indomethacin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Xing-kang& Zheng, Wenfang& Ding, Yu-e& Tang, Xia& Si, Jianmin& Sun, Leimin. 2018. Rectal Indomethacin Is Protective against Pancreatitis after Endoscopic Retrograde Cholangiopancreatography: Systematic Review and Meta-Analysis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1165995
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Xing-kang…[et al.]. Rectal Indomethacin Is Protective against Pancreatitis after Endoscopic Retrograde Cholangiopancreatography: Systematic Review and Meta-Analysis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1165995
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Xing-kang& Zheng, Wenfang& Ding, Yu-e& Tang, Xia& Si, Jianmin& Sun, Leimin. Rectal Indomethacin Is Protective against Pancreatitis after Endoscopic Retrograde Cholangiopancreatography: Systematic Review and Meta-Analysis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1165995
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1165995
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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