Rectal Indomethacin Is Protective against Pancreatitis after Endoscopic Retrograde Cholangiopancreatography: Systematic Review and Meta-Analysis
Joint Authors
Sun, Leimin
Si, Jianmin
He, Xing-kang
Ding, Yu-e
Zheng, Wenfang
Tang, Xia
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Aim.
Rectal indomethacin was reported to be effective for postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) prophylaxis.
However, the preventive effect of indomethacin for average-risk patients remains unclear.
Recently, some conflicting evidence was addressed by recent articles.
We aimed to determine the protective role of indomethacin in PEP based on the latest available literature.
Methods.
A systematic literature search was conducted using PubMed, Embase, Web of Science, and the Cochrane Library to identify related articles published before October 2016.
Studies that evaluated the administration of indomethacin in the prevention of PEP were included in the analysis.
We adopted a random-effects model to calculate the overall relative risk (RR) and 95% confidence interval (CI).
Results.
Ten trials from an initial search were finally included in the meta-analysis.
The administration of rectal indomethacin significantly reduced the incidence of PEP in consecutive ERCP population (RR, 0.63; 95% CI, 0.50–0.77).
There was no significant heterogeneity across included studies (I2=14.2%, P=0.31).
Further subgroup analyses also revealed that rectal indomethacin could protect the individuals at high and average risks and reduced severity of PEP.
Pre-ERCP administration of indomethacin seemed to be better than the post-ERCP given.
There was no evidence of significant publication bias.
Conclusions.
Rectal administration of indomethacin is an effective approach to prevent the incidence of PEP in both high- and average-risk populations undergoing ERCP.
However, more high-quality RCTs are needed to further investigate the optimal timing for the administration of indomethacin.
American Psychological Association (APA)
He, Xing-kang& Zheng, Wenfang& Ding, Yu-e& Tang, Xia& Si, Jianmin& Sun, Leimin. 2018. Rectal Indomethacin Is Protective against Pancreatitis after Endoscopic Retrograde Cholangiopancreatography: Systematic Review and Meta-Analysis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1165995
Modern Language Association (MLA)
He, Xing-kang…[et al.]. Rectal Indomethacin Is Protective against Pancreatitis after Endoscopic Retrograde Cholangiopancreatography: Systematic Review and Meta-Analysis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1165995
American Medical Association (AMA)
He, Xing-kang& Zheng, Wenfang& Ding, Yu-e& Tang, Xia& Si, Jianmin& Sun, Leimin. Rectal Indomethacin Is Protective against Pancreatitis after Endoscopic Retrograde Cholangiopancreatography: Systematic Review and Meta-Analysis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1165995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1165995