Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients
المؤلفون المشاركون
Cho, Won Kyoung
Park, So Hyun
Kim, Shin Hee
Cho, Kyoung Soon
Jang, Jung-Pil
Choi, Eun-Jeong
Ahn, Moonbae
Kim, Tai-Gyu
Jung, Min Ho
Baek, In Cheol
Suh, Byung-Kyu
المصدر
International Journal of Endocrinology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-20
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Toll-like receptors (TLRs) have been suggested to be associated with the development of AITD.
Methods.
Fifteen single-nucleotide polymorphisms in 7 TLR genes were analyzed in 104 Korean children (girls = 86, boys = 18) with AITD (Hashimoto disease (HD) = 44, Graves’ disease (GD) = 60, thyroid-associated ophthalmopathy (TAO) = 29, and non-TAO = 31) with 183 controls.
Results.
GD showed higher frequencies of the TLR4 rs1927911 C allele than control.
TAO showed a lower frequency of the TLR4 rs1927911 CT genotype and non-TAO showed a higher frequency of the TLR4 rs1927911 CC genotype than control.
The frequency of the TLR9 rs187084 CC genotype in TAO was higher than that in non-TAO.
GD females showed a higher frequency of the TLR4 rs10759932 T allele, rs1927911 CC genotype, and the rs1927911 C allele than controls.
GD males showed a higher frequency of the TLR4 rs10759932 CC genotype and rs1927911 TT genotype and lower frequency of the rs1927911 CT genotype than control.
The frequency of the TLR4 rs10759932 CC genotype, C allele and rs1927911 TT genotype, and T allele in a GD female were lower than in a GD male.
Conclusions.
Our results suggest that TLR4 and 9 polymorphisms might contribute to the pathogenesis of GD and TAO.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cho, Won Kyoung& Jang, Jung-Pil& Choi, Eun-Jeong& Ahn, Moonbae& Kim, Shin Hee& Cho, Kyoung Soon…[et al.]. 2017. Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166045
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cho, Won Kyoung…[et al.]. Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients. International Journal of Endocrinology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1166045
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cho, Won Kyoung& Jang, Jung-Pil& Choi, Eun-Jeong& Ahn, Moonbae& Kim, Shin Hee& Cho, Kyoung Soon…[et al.]. Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166045
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166045
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر