Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients

المؤلفون المشاركون

Cho, Won Kyoung
Park, So Hyun
Kim, Shin Hee
Cho, Kyoung Soon
Jang, Jung-Pil
Choi, Eun-Jeong
Ahn, Moonbae
Kim, Tai-Gyu
Jung, Min Ho
Baek, In Cheol
Suh, Byung-Kyu

المصدر

International Journal of Endocrinology

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-08-20

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأحياء

الملخص EN

Background.

Toll-like receptors (TLRs) have been suggested to be associated with the development of AITD.

Methods.

Fifteen single-nucleotide polymorphisms in 7 TLR genes were analyzed in 104 Korean children (girls = 86, boys = 18) with AITD (Hashimoto disease (HD) = 44, Graves’ disease (GD) = 60, thyroid-associated ophthalmopathy (TAO) = 29, and non-TAO = 31) with 183 controls.

Results.

GD showed higher frequencies of the TLR4 rs1927911 C allele than control.

TAO showed a lower frequency of the TLR4 rs1927911 CT genotype and non-TAO showed a higher frequency of the TLR4 rs1927911 CC genotype than control.

The frequency of the TLR9 rs187084 CC genotype in TAO was higher than that in non-TAO.

GD females showed a higher frequency of the TLR4 rs10759932 T allele, rs1927911 CC genotype, and the rs1927911 C allele than controls.

GD males showed a higher frequency of the TLR4 rs10759932 CC genotype and rs1927911 TT genotype and lower frequency of the rs1927911 CT genotype than control.

The frequency of the TLR4 rs10759932 CC genotype, C allele and rs1927911 TT genotype, and T allele in a GD female were lower than in a GD male.

Conclusions.

Our results suggest that TLR4 and 9 polymorphisms might contribute to the pathogenesis of GD and TAO.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Cho, Won Kyoung& Jang, Jung-Pil& Choi, Eun-Jeong& Ahn, Moonbae& Kim, Shin Hee& Cho, Kyoung Soon…[et al.]. 2017. Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166045

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Cho, Won Kyoung…[et al.]. Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients. International Journal of Endocrinology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1166045

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Cho, Won Kyoung& Jang, Jung-Pil& Choi, Eun-Jeong& Ahn, Moonbae& Kim, Shin Hee& Cho, Kyoung Soon…[et al.]. Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166045

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1166045