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Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients
Joint Authors
Cho, Won Kyoung
Park, So Hyun
Kim, Shin Hee
Cho, Kyoung Soon
Jang, Jung-Pil
Choi, Eun-Jeong
Ahn, Moonbae
Kim, Tai-Gyu
Jung, Min Ho
Baek, In Cheol
Suh, Byung-Kyu
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Toll-like receptors (TLRs) have been suggested to be associated with the development of AITD.
Methods.
Fifteen single-nucleotide polymorphisms in 7 TLR genes were analyzed in 104 Korean children (girls = 86, boys = 18) with AITD (Hashimoto disease (HD) = 44, Graves’ disease (GD) = 60, thyroid-associated ophthalmopathy (TAO) = 29, and non-TAO = 31) with 183 controls.
Results.
GD showed higher frequencies of the TLR4 rs1927911 C allele than control.
TAO showed a lower frequency of the TLR4 rs1927911 CT genotype and non-TAO showed a higher frequency of the TLR4 rs1927911 CC genotype than control.
The frequency of the TLR9 rs187084 CC genotype in TAO was higher than that in non-TAO.
GD females showed a higher frequency of the TLR4 rs10759932 T allele, rs1927911 CC genotype, and the rs1927911 C allele than controls.
GD males showed a higher frequency of the TLR4 rs10759932 CC genotype and rs1927911 TT genotype and lower frequency of the rs1927911 CT genotype than control.
The frequency of the TLR4 rs10759932 CC genotype, C allele and rs1927911 TT genotype, and T allele in a GD female were lower than in a GD male.
Conclusions.
Our results suggest that TLR4 and 9 polymorphisms might contribute to the pathogenesis of GD and TAO.
American Psychological Association (APA)
Cho, Won Kyoung& Jang, Jung-Pil& Choi, Eun-Jeong& Ahn, Moonbae& Kim, Shin Hee& Cho, Kyoung Soon…[et al.]. 2017. Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166045
Modern Language Association (MLA)
Cho, Won Kyoung…[et al.]. Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients. International Journal of Endocrinology No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1166045
American Medical Association (AMA)
Cho, Won Kyoung& Jang, Jung-Pil& Choi, Eun-Jeong& Ahn, Moonbae& Kim, Shin Hee& Cho, Kyoung Soon…[et al.]. Association of Polymorphisms in Toll-Like Receptors 4 and 9 with Autoimmune Thyroid Disease in Korean Pediatric Patients. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1166045
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166045