![](/images/graphics-bg.png)
Efficacy of Once Daily versus Divided Daily Administration of Low Daily Dosage (15 mgDay) of Methimazole in the Induction of Euthyroidism in Graves’ Hyperthyroidism: A Randomized Controlled Study
المؤلفون المشاركون
Lertwattanarak, Raweewan
Sriussadaporn, Sutin
Pumchumpol, Wanwaroon
Kunavisarut, Tada
المصدر
International Journal of Endocrinology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Previous studies used unequal or high daily dosages of methimazole (MMI) to compare the efficacy of once daily dose regimen (OD-MMI) with that of divided daily doses regimen (DD-MMI) in inducing euthyroidism.
Objectives.
To compare the efficacy of OD-MMI to that of DD-MMI using low daily dosage of MMI in inducing euthyroidism.
Methods.
Fifty patients with clinically nonsevere Graves’ hyperthyroidism were randomized to be treated with 15 mg/day OD-MMI or 15 mg/day DD-MMI.
Results.
21 cases (84%) in OD-MMI and 23 cases (92%) in DD-MMI were eligible for analyses.
During the treatment, there was no difference in baseline characteristics, serum FT3 and FT4 reductions, and cumulative rate of achieving euthyroidism (4.8% versus 4.3%, 28.6% versus 34.8%, 71.4% versus 82.6%, and 85.7% versus 87.0% at 2, 4, 8, and 12 weeks, resp.) between both regimens.
Hypothyroidism developed in DD-MMI significantly more than in OD-MMI (17.4% versus 0%, p<0.05).
Conclusions.
Treatment with MMI at a low daily dosage of 15 mg/day OD-MMI is as effective as DD-MMI in the reduction of serum thyroid hormone levels and induction of euthyroidism.
The OD-MMI regimen is preferable to the DD-MMI regimen in the treatment of clinically nonsevere Graves’ hyperthyroidism.
This trial is registered with Thai Clinical Trials Registry: TCTR20170529001.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sriussadaporn, Sutin& Pumchumpol, Wanwaroon& Lertwattanarak, Raweewan& Kunavisarut, Tada. 2017. Efficacy of Once Daily versus Divided Daily Administration of Low Daily Dosage (15 mgDay) of Methimazole in the Induction of Euthyroidism in Graves’ Hyperthyroidism: A Randomized Controlled Study. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166064
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sriussadaporn, Sutin…[et al.]. Efficacy of Once Daily versus Divided Daily Administration of Low Daily Dosage (15 mgDay) of Methimazole in the Induction of Euthyroidism in Graves’ Hyperthyroidism: A Randomized Controlled Study. International Journal of Endocrinology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1166064
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sriussadaporn, Sutin& Pumchumpol, Wanwaroon& Lertwattanarak, Raweewan& Kunavisarut, Tada. Efficacy of Once Daily versus Divided Daily Administration of Low Daily Dosage (15 mgDay) of Methimazole in the Induction of Euthyroidism in Graves’ Hyperthyroidism: A Randomized Controlled Study. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166064
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166064
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)