Efficacy of Once Daily versus Divided Daily Administration of Low Daily Dosage (15 mgDay) of Methimazole in the Induction of Euthyroidism in Graves’ Hyperthyroidism: A Randomized Controlled Study
Joint Authors
Lertwattanarak, Raweewan
Sriussadaporn, Sutin
Pumchumpol, Wanwaroon
Kunavisarut, Tada
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Previous studies used unequal or high daily dosages of methimazole (MMI) to compare the efficacy of once daily dose regimen (OD-MMI) with that of divided daily doses regimen (DD-MMI) in inducing euthyroidism.
Objectives.
To compare the efficacy of OD-MMI to that of DD-MMI using low daily dosage of MMI in inducing euthyroidism.
Methods.
Fifty patients with clinically nonsevere Graves’ hyperthyroidism were randomized to be treated with 15 mg/day OD-MMI or 15 mg/day DD-MMI.
Results.
21 cases (84%) in OD-MMI and 23 cases (92%) in DD-MMI were eligible for analyses.
During the treatment, there was no difference in baseline characteristics, serum FT3 and FT4 reductions, and cumulative rate of achieving euthyroidism (4.8% versus 4.3%, 28.6% versus 34.8%, 71.4% versus 82.6%, and 85.7% versus 87.0% at 2, 4, 8, and 12 weeks, resp.) between both regimens.
Hypothyroidism developed in DD-MMI significantly more than in OD-MMI (17.4% versus 0%, p<0.05).
Conclusions.
Treatment with MMI at a low daily dosage of 15 mg/day OD-MMI is as effective as DD-MMI in the reduction of serum thyroid hormone levels and induction of euthyroidism.
The OD-MMI regimen is preferable to the DD-MMI regimen in the treatment of clinically nonsevere Graves’ hyperthyroidism.
This trial is registered with Thai Clinical Trials Registry: TCTR20170529001.
American Psychological Association (APA)
Sriussadaporn, Sutin& Pumchumpol, Wanwaroon& Lertwattanarak, Raweewan& Kunavisarut, Tada. 2017. Efficacy of Once Daily versus Divided Daily Administration of Low Daily Dosage (15 mgDay) of Methimazole in the Induction of Euthyroidism in Graves’ Hyperthyroidism: A Randomized Controlled Study. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166064
Modern Language Association (MLA)
Sriussadaporn, Sutin…[et al.]. Efficacy of Once Daily versus Divided Daily Administration of Low Daily Dosage (15 mgDay) of Methimazole in the Induction of Euthyroidism in Graves’ Hyperthyroidism: A Randomized Controlled Study. International Journal of Endocrinology No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1166064
American Medical Association (AMA)
Sriussadaporn, Sutin& Pumchumpol, Wanwaroon& Lertwattanarak, Raweewan& Kunavisarut, Tada. Efficacy of Once Daily versus Divided Daily Administration of Low Daily Dosage (15 mgDay) of Methimazole in the Induction of Euthyroidism in Graves’ Hyperthyroidism: A Randomized Controlled Study. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1166064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166064