Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species
المؤلفون المشاركون
Locke, Jeffrey B.
Almaguer, Amanda L.
Donatelli, Joanna L.
Bartizal, Ken F.
المصدر
Infectious Diseases in Obstetrics and Gynecology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
While echinocandins demonstrate excellent efficacy against Candida species in disseminated infections and demonstrate potent minimal inhibitory concentration (MIC) values under standard susceptibility testing conditions, investigation under conditions relevant to the vaginal environment was needed.
We assessed the antifungal activity and time-kill kinetics of the novel echinocandin rezafungin (formerly CD101) under such conditions, against Candida species relevant to vulvovaginal candidiasis (VVC).
Methods.
Susceptibility testing of fluconazole-susceptible and fluconazole-resistant C.
albicans, C.
glabrata, C.
tropicalis, C.
parapsilosis, and C.
krusei was performed in RPMI at pH 7.0 and in vagina-simulative medium (VSM) at pH 4.2 for topical rezafungin, terconazole, fluconazole, and amphotericin B.
Time-kill kinetics were evaluated for rezafungin and terconazole at 2, 8, 32, and 128 μg/ml over 72 hours.
Results.
Rezafungin MIC values were the same or 2-fold higher in VSM/pH 4.2 versus RPMI/pH 7.0.
Some C.
albicans terconazole MIC values were lower, but most were significantly higher in VSM than in RPMI.
Rezafungin was fungicidal against 11/14 strains and near-fungicidal against the others.
Terconazole (128 μg/ml) was fungicidal against C.
krusei and near-fungicidal against susceptible C.
parapsilosis but fungistatic versus all other strains evaluated.
Conclusion.
Rezafungin retained anti-Candida activity and fungicidal activity under in vitro conditions relevant to VVC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Locke, Jeffrey B.& Almaguer, Amanda L.& Donatelli, Joanna L.& Bartizal, Ken F.. 2018. Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species. Infectious Diseases in Obstetrics and Gynecology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1166091
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Locke, Jeffrey B.…[et al.]. Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species. Infectious Diseases in Obstetrics and Gynecology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1166091
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Locke, Jeffrey B.& Almaguer, Amanda L.& Donatelli, Joanna L.& Bartizal, Ken F.. Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species. Infectious Diseases in Obstetrics and Gynecology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1166091
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166091
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر