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Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species
Joint Authors
Locke, Jeffrey B.
Almaguer, Amanda L.
Donatelli, Joanna L.
Bartizal, Ken F.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
While echinocandins demonstrate excellent efficacy against Candida species in disseminated infections and demonstrate potent minimal inhibitory concentration (MIC) values under standard susceptibility testing conditions, investigation under conditions relevant to the vaginal environment was needed.
We assessed the antifungal activity and time-kill kinetics of the novel echinocandin rezafungin (formerly CD101) under such conditions, against Candida species relevant to vulvovaginal candidiasis (VVC).
Methods.
Susceptibility testing of fluconazole-susceptible and fluconazole-resistant C.
albicans, C.
glabrata, C.
tropicalis, C.
parapsilosis, and C.
krusei was performed in RPMI at pH 7.0 and in vagina-simulative medium (VSM) at pH 4.2 for topical rezafungin, terconazole, fluconazole, and amphotericin B.
Time-kill kinetics were evaluated for rezafungin and terconazole at 2, 8, 32, and 128 μg/ml over 72 hours.
Results.
Rezafungin MIC values were the same or 2-fold higher in VSM/pH 4.2 versus RPMI/pH 7.0.
Some C.
albicans terconazole MIC values were lower, but most were significantly higher in VSM than in RPMI.
Rezafungin was fungicidal against 11/14 strains and near-fungicidal against the others.
Terconazole (128 μg/ml) was fungicidal against C.
krusei and near-fungicidal against susceptible C.
parapsilosis but fungistatic versus all other strains evaluated.
Conclusion.
Rezafungin retained anti-Candida activity and fungicidal activity under in vitro conditions relevant to VVC.
American Psychological Association (APA)
Locke, Jeffrey B.& Almaguer, Amanda L.& Donatelli, Joanna L.& Bartizal, Ken F.. 2018. Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species. Infectious Diseases in Obstetrics and Gynecology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1166091
Modern Language Association (MLA)
Locke, Jeffrey B.…[et al.]. Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species. Infectious Diseases in Obstetrics and Gynecology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1166091
American Medical Association (AMA)
Locke, Jeffrey B.& Almaguer, Amanda L.& Donatelli, Joanna L.& Bartizal, Ken F.. Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species. Infectious Diseases in Obstetrics and Gynecology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1166091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166091