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The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules
المؤلفون المشاركون
Arpaci, Dilek
Köktürk, Füruzan
Can, Murat
Kuzu, Fatih
Unal, Mustafa
Altas, Ayfer
Ilikhan, Sevil Uygun
Bayraktaroglu, Taner
Barut, Figen
المصدر
International Journal of Endocrinology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aim.
Insulin-like growth factor-1 (IGF-1) is a potent mitogen for many cells.
IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties.
The aim of this study was to determine both the serum and intranodular levels of IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with nodular thyroid diseases.
Materials and Methods.
In this study, 80 subjects who performed fine-needle aspiration biopsy (FNAB) were required in order to investigate the effects of serum and intranodular IGF-1 and IGFBP-3 in the pathogenesis of nodules.
After performing FNAB, IGF-1 and IGFBP-3 levels were determined in blood and aspiration samples.
Results.
The serum levels of IGF-1 (232.8 ± 12.9 ng/ml) and IGFBP-3 (4.8 μg/ml) were found significantly higher than that of the intranodular IGF-1 (39.1 ng/ml) and intranodular IGFBP-3 levels (0.173 μg/ml) (p<0.01).
Intranodular levels of IGF-1 and IGFBP-3 were higher in subjects with multinodular thyroid gland than those of subjects with solitary nodules (p=0.043).
A positive correlation between the nodule size and the serum IGFBP-3 levels was detected (p=0.042, r=0.23).
Conclusion.
This study demonstrated the possible role of both IGF-1 and IGFBP-3 in the growth and the formation of multinodularity of thyroid nodules.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Altas, Ayfer& Kuzu, Fatih& Arpaci, Dilek& Unal, Mustafa& Can, Murat& Barut, Figen…[et al.]. 2017. The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1166124
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Altas, Ayfer…[et al.]. The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules. International Journal of Endocrinology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1166124
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Altas, Ayfer& Kuzu, Fatih& Arpaci, Dilek& Unal, Mustafa& Can, Murat& Barut, Figen…[et al.]. The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1166124
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166124
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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