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The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules
Joint Authors
Arpaci, Dilek
Köktürk, Füruzan
Can, Murat
Kuzu, Fatih
Unal, Mustafa
Altas, Ayfer
Ilikhan, Sevil Uygun
Bayraktaroglu, Taner
Barut, Figen
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aim.
Insulin-like growth factor-1 (IGF-1) is a potent mitogen for many cells.
IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties.
The aim of this study was to determine both the serum and intranodular levels of IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with nodular thyroid diseases.
Materials and Methods.
In this study, 80 subjects who performed fine-needle aspiration biopsy (FNAB) were required in order to investigate the effects of serum and intranodular IGF-1 and IGFBP-3 in the pathogenesis of nodules.
After performing FNAB, IGF-1 and IGFBP-3 levels were determined in blood and aspiration samples.
Results.
The serum levels of IGF-1 (232.8 ± 12.9 ng/ml) and IGFBP-3 (4.8 μg/ml) were found significantly higher than that of the intranodular IGF-1 (39.1 ng/ml) and intranodular IGFBP-3 levels (0.173 μg/ml) (p<0.01).
Intranodular levels of IGF-1 and IGFBP-3 were higher in subjects with multinodular thyroid gland than those of subjects with solitary nodules (p=0.043).
A positive correlation between the nodule size and the serum IGFBP-3 levels was detected (p=0.042, r=0.23).
Conclusion.
This study demonstrated the possible role of both IGF-1 and IGFBP-3 in the growth and the formation of multinodularity of thyroid nodules.
American Psychological Association (APA)
Altas, Ayfer& Kuzu, Fatih& Arpaci, Dilek& Unal, Mustafa& Can, Murat& Barut, Figen…[et al.]. 2017. The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1166124
Modern Language Association (MLA)
Altas, Ayfer…[et al.]. The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules. International Journal of Endocrinology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1166124
American Medical Association (AMA)
Altas, Ayfer& Kuzu, Fatih& Arpaci, Dilek& Unal, Mustafa& Can, Murat& Barut, Figen…[et al.]. The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1166124
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166124