Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease
المؤلفون المشاركون
Yao, Qiu-ming
Wang, Wen
Song, Rong-hua
Zhang, Jin-an
Li, Qian
Shao, Xiao-qing
المصدر
International Journal of Endocrinology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
As there are no previous studies on the interleukin-22 (IL-22) variants in autoimmune thyroid disease (AITD), the present study aimed to explore the association between polymorphisms of IL-22 and the predisposition to AITD.
The study had 975 AITD patients, including 639 Graves’ disease (GD) and 336 Hashimoto’s thyroiditis (HT) individuals and 851 healthy cohorts.
Ligase detection reaction (LDR) and direct sequencing method were used for genotyping the IL-22 gene polymorphisms at rs2046068, rs2227478, rs2227485, rs11611206, and rs1179251.
In comparison to female controls, genotype CC of rs1179251 was increased in the female AITD patients.
Alleles C at rs2046068, C at rs2227478, and C at rs1179251 linked to the susceptibility of HT males.
Genotype CC in rs1179251 was higher in male HT.
Variants at rs2046068, rs2227478, and rs1179251 were associated with the AITD teenagers.
Besides, genotype GG in rs11611206 was correlated with thyroid-associated ophthalmopathy (TAO).
Moreover, allele G at rs11611206 was associated with decreased risk for TAO by 28.9%.
Similarly, genotype CC of rs1179251 and genotype GG of rs11611206 were associated with Graves’ ophthalmopathy (GO).
Allele G in rs11611206 increased people with HT towards the predisposition of hypothyroidism.
In conclusion, genetic variants of IL-22 are associated with the occurrence of AITD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Rong-hua& Li, Qian& Wang, Wen& Yao, Qiu-ming& Shao, Xiao-qing& Zhang, Jin-an. 2017. Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166156
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Rong-hua…[et al.]. Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease. International Journal of Endocrinology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166156
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Rong-hua& Li, Qian& Wang, Wen& Yao, Qiu-ming& Shao, Xiao-qing& Zhang, Jin-an. Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166156
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166156
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر