Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease
Joint Authors
Yao, Qiu-ming
Wang, Wen
Song, Rong-hua
Zhang, Jin-an
Li, Qian
Shao, Xiao-qing
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
As there are no previous studies on the interleukin-22 (IL-22) variants in autoimmune thyroid disease (AITD), the present study aimed to explore the association between polymorphisms of IL-22 and the predisposition to AITD.
The study had 975 AITD patients, including 639 Graves’ disease (GD) and 336 Hashimoto’s thyroiditis (HT) individuals and 851 healthy cohorts.
Ligase detection reaction (LDR) and direct sequencing method were used for genotyping the IL-22 gene polymorphisms at rs2046068, rs2227478, rs2227485, rs11611206, and rs1179251.
In comparison to female controls, genotype CC of rs1179251 was increased in the female AITD patients.
Alleles C at rs2046068, C at rs2227478, and C at rs1179251 linked to the susceptibility of HT males.
Genotype CC in rs1179251 was higher in male HT.
Variants at rs2046068, rs2227478, and rs1179251 were associated with the AITD teenagers.
Besides, genotype GG in rs11611206 was correlated with thyroid-associated ophthalmopathy (TAO).
Moreover, allele G at rs11611206 was associated with decreased risk for TAO by 28.9%.
Similarly, genotype CC of rs1179251 and genotype GG of rs11611206 were associated with Graves’ ophthalmopathy (GO).
Allele G in rs11611206 increased people with HT towards the predisposition of hypothyroidism.
In conclusion, genetic variants of IL-22 are associated with the occurrence of AITD.
American Psychological Association (APA)
Song, Rong-hua& Li, Qian& Wang, Wen& Yao, Qiu-ming& Shao, Xiao-qing& Zhang, Jin-an. 2017. Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166156
Modern Language Association (MLA)
Song, Rong-hua…[et al.]. Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease. International Journal of Endocrinology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166156
American Medical Association (AMA)
Song, Rong-hua& Li, Qian& Wang, Wen& Yao, Qiu-ming& Shao, Xiao-qing& Zhang, Jin-an. Variants of Interleukin-22 Gene Confer Predisposition to Autoimmune Thyroid Disease. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166156