Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures
المؤلفون المشاركون
Canhão, Helena
de Mello-Sampayo, Cristina
Agripino, Alaíde Alves
Stilwell, Duarte
Vidal, Bruno
Fernando, Ana Luisa
Silva-Lima, Beatriz
Vaz, Maria Fátima
Marques, M. Cristina
المصدر
International Journal of Endocrinology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-07
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
There is controversy concerning the diabetes impact on bone quality, notorious in type 2 diabetic postmenopausal women.
One pointed cause might be uncontrolled glycemia.
In this study, the effect of chronic hyperglycemia in bone turnover, morphology, and biomechanics was evaluated in female Wistar rats in the presence/absence of estrogens (ovariectomy).
Animals (n=28) were divided into sham, ovariectomized (OVX), hyperglycemic (streptozotocin 40 mg/kg, single-dose i.p.-STZ), and hyperglycemic-ovariectomized (STZ + OVX) animals.
Blood biomarkers were estimated 60 days postovariectomy.
Body weight, vertebral microarchitecture (L4-histomorphometry), femur biomechanical properties (bending tests), tibia ultrastructure (scanning electron microscopy), and femur and urinary calcium (atomic absorption) were also evaluated.
The increased PINP/CTX ratio of hyperglycemic animals and the similar ratio between STZ + OVX and healthy animals contrasting with the lower ratio of OVX (in line with its histomorphometric data) suggest a tendency for improved bone formation in hyperglycemic-ovariectomized animals.
The increased tibia medullar canal, which contrasts with the unaffected cortical thickness of both hyperglycemic groups while that of OVX decreased, was associated to the increased stiffness and strength of STZ + OVX bones compared to those of OVX, in line with the observed ultrastructure.
Concluding, chronic hyperglycemia in ovariectomized female rats causes bone morphological changes that translate positively in the ultrastructure and mechanical properties of cortical bones.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Mello-Sampayo, Cristina& Agripino, Alaíde Alves& Stilwell, Duarte& Vidal, Bruno& Fernando, Ana Luisa& Silva-Lima, Beatriz…[et al.]. 2017. Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166229
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Mello-Sampayo, Cristina…[et al.]. Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures. International Journal of Endocrinology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166229
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Mello-Sampayo, Cristina& Agripino, Alaíde Alves& Stilwell, Duarte& Vidal, Bruno& Fernando, Ana Luisa& Silva-Lima, Beatriz…[et al.]. Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166229
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166229
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر