Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures
Joint Authors
Canhão, Helena
de Mello-Sampayo, Cristina
Agripino, Alaíde Alves
Stilwell, Duarte
Vidal, Bruno
Fernando, Ana Luisa
Silva-Lima, Beatriz
Vaz, Maria Fátima
Marques, M. Cristina
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
There is controversy concerning the diabetes impact on bone quality, notorious in type 2 diabetic postmenopausal women.
One pointed cause might be uncontrolled glycemia.
In this study, the effect of chronic hyperglycemia in bone turnover, morphology, and biomechanics was evaluated in female Wistar rats in the presence/absence of estrogens (ovariectomy).
Animals (n=28) were divided into sham, ovariectomized (OVX), hyperglycemic (streptozotocin 40 mg/kg, single-dose i.p.-STZ), and hyperglycemic-ovariectomized (STZ + OVX) animals.
Blood biomarkers were estimated 60 days postovariectomy.
Body weight, vertebral microarchitecture (L4-histomorphometry), femur biomechanical properties (bending tests), tibia ultrastructure (scanning electron microscopy), and femur and urinary calcium (atomic absorption) were also evaluated.
The increased PINP/CTX ratio of hyperglycemic animals and the similar ratio between STZ + OVX and healthy animals contrasting with the lower ratio of OVX (in line with its histomorphometric data) suggest a tendency for improved bone formation in hyperglycemic-ovariectomized animals.
The increased tibia medullar canal, which contrasts with the unaffected cortical thickness of both hyperglycemic groups while that of OVX decreased, was associated to the increased stiffness and strength of STZ + OVX bones compared to those of OVX, in line with the observed ultrastructure.
Concluding, chronic hyperglycemia in ovariectomized female rats causes bone morphological changes that translate positively in the ultrastructure and mechanical properties of cortical bones.
American Psychological Association (APA)
de Mello-Sampayo, Cristina& Agripino, Alaíde Alves& Stilwell, Duarte& Vidal, Bruno& Fernando, Ana Luisa& Silva-Lima, Beatriz…[et al.]. 2017. Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166229
Modern Language Association (MLA)
de Mello-Sampayo, Cristina…[et al.]. Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures. International Journal of Endocrinology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1166229
American Medical Association (AMA)
de Mello-Sampayo, Cristina& Agripino, Alaíde Alves& Stilwell, Duarte& Vidal, Bruno& Fernando, Ana Luisa& Silva-Lima, Beatriz…[et al.]. Chronic Hyperglycemia Modulates Rat Osteoporotic Cortical Bone Microarchitecture into Less Fragile Structures. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1166229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166229