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Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function in Healthy Individuals
المؤلفون المشاركون
Liu, Juan
Cao, Xiaopei
Li, Yanbing
Liu, Liehua
Liu, Jianbin
Huang, Zhimin
Li, Hai
Zheng, Jing
Xiao, Haipeng
المصدر
International Journal of Endocrinology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the relationship between abdominal adipose tissue distribution, β-cell function, and insulin sensitivity (IS) in a Chinese population.
Methods.
One hundred and eighty-eight healthy subjects (healthy group), 239 with normal glucose, and 1~4 abnormal metabolic traits (metabolic dysfunction group, MD group) and 125 with hyperglycemia (hyperglycemia group) were studied.
HOMA-IR, HOMA-B, Matsuda index, early- (I0–30/G0–30) and late-phase (I30–120/G30–120) insulin responses and the corresponding disposition indexes (DI) were calculated.
The area of abdominal subcutaneous adipose tissue (ASAT) and visceral adipose tissue (VAT) was measured and the ratio of ASAT to VAT (SVR) was calculated.
Results.
SVR was correlated positively with Matsuda index in healthy, MD, and hyperglycemia groups, and inversely with HOMA-IR.
SVR positively related with both early- and late-phase DI in the healthy group only.
In the healthy group, the hyperbolas of I0–30/G0–30 and I30–120/G30–120 versus Matsuda index in the highest quarter of SVR were significantly right shifted compared to those in the lowest (both P<0.05).
Conclusions.
In healthy adults, higher SVR was a protective factor for β-cell function and IS, while in those with glucometabolic abnormality, higher SVR contributed to a relative better IS, indicating SVR is possible to be an early predicator of type 2 diabetes development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Juan& Liu, Jianbin& Li, Hai& Liu, Liehua& Zheng, Jing& Huang, Zhimin…[et al.]. 2017. Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function in Healthy Individuals. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1166504
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Juan…[et al.]. Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function in Healthy Individuals. International Journal of Endocrinology No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1166504
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Juan& Liu, Jianbin& Li, Hai& Liu, Liehua& Zheng, Jing& Huang, Zhimin…[et al.]. Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function in Healthy Individuals. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1166504
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166504
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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