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Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function in Healthy Individuals
Joint Authors
Liu, Juan
Cao, Xiaopei
Li, Yanbing
Liu, Liehua
Liu, Jianbin
Huang, Zhimin
Li, Hai
Zheng, Jing
Xiao, Haipeng
Source
International Journal of Endocrinology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To investigate the relationship between abdominal adipose tissue distribution, β-cell function, and insulin sensitivity (IS) in a Chinese population.
Methods.
One hundred and eighty-eight healthy subjects (healthy group), 239 with normal glucose, and 1~4 abnormal metabolic traits (metabolic dysfunction group, MD group) and 125 with hyperglycemia (hyperglycemia group) were studied.
HOMA-IR, HOMA-B, Matsuda index, early- (I0–30/G0–30) and late-phase (I30–120/G30–120) insulin responses and the corresponding disposition indexes (DI) were calculated.
The area of abdominal subcutaneous adipose tissue (ASAT) and visceral adipose tissue (VAT) was measured and the ratio of ASAT to VAT (SVR) was calculated.
Results.
SVR was correlated positively with Matsuda index in healthy, MD, and hyperglycemia groups, and inversely with HOMA-IR.
SVR positively related with both early- and late-phase DI in the healthy group only.
In the healthy group, the hyperbolas of I0–30/G0–30 and I30–120/G30–120 versus Matsuda index in the highest quarter of SVR were significantly right shifted compared to those in the lowest (both P<0.05).
Conclusions.
In healthy adults, higher SVR was a protective factor for β-cell function and IS, while in those with glucometabolic abnormality, higher SVR contributed to a relative better IS, indicating SVR is possible to be an early predicator of type 2 diabetes development.
American Psychological Association (APA)
Liu, Juan& Liu, Jianbin& Li, Hai& Liu, Liehua& Zheng, Jing& Huang, Zhimin…[et al.]. 2017. Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function in Healthy Individuals. International Journal of Endocrinology،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1166504
Modern Language Association (MLA)
Liu, Juan…[et al.]. Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function in Healthy Individuals. International Journal of Endocrinology No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1166504
American Medical Association (AMA)
Liu, Juan& Liu, Jianbin& Li, Hai& Liu, Liehua& Zheng, Jing& Huang, Zhimin…[et al.]. Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function in Healthy Individuals. International Journal of Endocrinology. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1166504
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166504