Combination Use of Tegafur and Apatinib as First-Line Therapy in Treatment of Advanced Gastric Cancer: A Single-Blinded Randomized Study
المؤلفون المشاركون
Li, Chaofeng
Tang, Tao
Wang, Wenyue
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-06
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the efficacy and safety of the combination use of tegafur and apatinib as a first-line therapy strategy in advanced gastric cancer (GC).
Methods.
The present study included a total of 62 advanced GC patients.
The patients were randomized into the combined group (treated with both tegafur and apatinib) and the control group (treated with only tegafur).
Treatment efficacy, KPS score, nutrition condition, and progression-free survival time (PFS) were recorded.
Results.
Both the response and disease control rates were significantly higher in the combined group.
The PFS time was remarkably higher and the KPS score was significantly reduced in the combined group after treatment.
After treatment, both groups showed significantly increased nutrition risk, but the rates of patients with nutrition risk or innutrition were remarkably higher in the combined group.
The ADR rates were also significantly higher in the combined group.
Conclusion.
The combination use could achieve good efficacy and prolong patients’ PFS time; however, apatinib also reduced the patients’ quality of life and enhanced the nutrition risk and adverse drug reactions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Chaofeng& Tang, Tao& Wang, Wenyue. 2020. Combination Use of Tegafur and Apatinib as First-Line Therapy in Treatment of Advanced Gastric Cancer: A Single-Blinded Randomized Study. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1166749
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Chaofeng…[et al.]. Combination Use of Tegafur and Apatinib as First-Line Therapy in Treatment of Advanced Gastric Cancer: A Single-Blinded Randomized Study. Gastroenterology Research and Practice No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1166749
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Chaofeng& Tang, Tao& Wang, Wenyue. Combination Use of Tegafur and Apatinib as First-Line Therapy in Treatment of Advanced Gastric Cancer: A Single-Blinded Randomized Study. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1166749
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1166749
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر