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Combination Use of Tegafur and Apatinib as First-Line Therapy in Treatment of Advanced Gastric Cancer: A Single-Blinded Randomized Study
Joint Authors
Li, Chaofeng
Tang, Tao
Wang, Wenyue
Source
Gastroenterology Research and Practice
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To investigate the efficacy and safety of the combination use of tegafur and apatinib as a first-line therapy strategy in advanced gastric cancer (GC).
Methods.
The present study included a total of 62 advanced GC patients.
The patients were randomized into the combined group (treated with both tegafur and apatinib) and the control group (treated with only tegafur).
Treatment efficacy, KPS score, nutrition condition, and progression-free survival time (PFS) were recorded.
Results.
Both the response and disease control rates were significantly higher in the combined group.
The PFS time was remarkably higher and the KPS score was significantly reduced in the combined group after treatment.
After treatment, both groups showed significantly increased nutrition risk, but the rates of patients with nutrition risk or innutrition were remarkably higher in the combined group.
The ADR rates were also significantly higher in the combined group.
Conclusion.
The combination use could achieve good efficacy and prolong patients’ PFS time; however, apatinib also reduced the patients’ quality of life and enhanced the nutrition risk and adverse drug reactions.
American Psychological Association (APA)
Li, Chaofeng& Tang, Tao& Wang, Wenyue. 2020. Combination Use of Tegafur and Apatinib as First-Line Therapy in Treatment of Advanced Gastric Cancer: A Single-Blinded Randomized Study. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1166749
Modern Language Association (MLA)
Li, Chaofeng…[et al.]. Combination Use of Tegafur and Apatinib as First-Line Therapy in Treatment of Advanced Gastric Cancer: A Single-Blinded Randomized Study. Gastroenterology Research and Practice No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1166749
American Medical Association (AMA)
Li, Chaofeng& Tang, Tao& Wang, Wenyue. Combination Use of Tegafur and Apatinib as First-Line Therapy in Treatment of Advanced Gastric Cancer: A Single-Blinded Randomized Study. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1166749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1166749