Differential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML
المؤلفون المشاركون
Mohamed, Zahurin
Islam, Mirazul
Assenov, Yassen
المصدر
International Journal of Genomics
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-20
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Acute myeloid leukemia (AML) is a haematological malignancy characterized by the excessive proliferation of immature myeloid cells coupled with impaired differentiation.
Many AML cases have been reported without any known cytogenetic abnormalities and carry no mutation in known AML-associated driver genes.
In this study, 200 AML cases were selected from a publicly available cohort and differentially analyzed for genetic, epigenetic, and cytogenetic abnormalities.
Three genes (FLT3, DNMT3A, and NPMc) are found to be predominantly mutated.
We identified several aberrations to be associated with genome-wide methylation changes.
These include Del (5q), T (15; 17), and NPMc mutations.
Four aberrations—Del (5q), T (15; 17), T (9; 22), and T (9; 11)—are significantly associated with patient survival.
Del (5q)-positive patients have an average survival of less than 1 year, whereas T (15; 17)-positive patients have a significantly better prognosis.
Combining the methylation and mutation data reveals three distinct patient groups and four clusters of genes.
We speculate that combined signatures have the better potential to be used for subclassification of AML, complementing cytogenetic signatures.
A larger sample cohort and further investigation of the effects observed in this study are required to enable the clinical application of our patient classification aided by DNA methylation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Islam, Mirazul& Mohamed, Zahurin& Assenov, Yassen. 2017. Differential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1167035
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Islam, Mirazul…[et al.]. Differential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML. International Journal of Genomics No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1167035
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Islam, Mirazul& Mohamed, Zahurin& Assenov, Yassen. Differential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1167035
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167035
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر