Differential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML
Joint Authors
Mohamed, Zahurin
Islam, Mirazul
Assenov, Yassen
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Acute myeloid leukemia (AML) is a haematological malignancy characterized by the excessive proliferation of immature myeloid cells coupled with impaired differentiation.
Many AML cases have been reported without any known cytogenetic abnormalities and carry no mutation in known AML-associated driver genes.
In this study, 200 AML cases were selected from a publicly available cohort and differentially analyzed for genetic, epigenetic, and cytogenetic abnormalities.
Three genes (FLT3, DNMT3A, and NPMc) are found to be predominantly mutated.
We identified several aberrations to be associated with genome-wide methylation changes.
These include Del (5q), T (15; 17), and NPMc mutations.
Four aberrations—Del (5q), T (15; 17), T (9; 22), and T (9; 11)—are significantly associated with patient survival.
Del (5q)-positive patients have an average survival of less than 1 year, whereas T (15; 17)-positive patients have a significantly better prognosis.
Combining the methylation and mutation data reveals three distinct patient groups and four clusters of genes.
We speculate that combined signatures have the better potential to be used for subclassification of AML, complementing cytogenetic signatures.
A larger sample cohort and further investigation of the effects observed in this study are required to enable the clinical application of our patient classification aided by DNA methylation.
American Psychological Association (APA)
Islam, Mirazul& Mohamed, Zahurin& Assenov, Yassen. 2017. Differential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1167035
Modern Language Association (MLA)
Islam, Mirazul…[et al.]. Differential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML. International Journal of Genomics No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1167035
American Medical Association (AMA)
Islam, Mirazul& Mohamed, Zahurin& Assenov, Yassen. Differential Analysis of Genetic, Epigenetic, and Cytogenetic Abnormalities in AML. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1167035
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167035