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Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer
المؤلفون المشاركون
Purrello, Michele
Ragusa, Marco
Barbagallo, Cristina
Brex, Duilia
Caponnetto, Angela
Cirnigliaro, Matilde
Battaglia, Rosalia
Barbagallo, Davide
Di Pietro, Cinzia
المصدر
International Journal of Genomics
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-24
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Over the past few years, noncoding RNAs (ncRNAs) have been extensively studied because of the significant biological roles that they play in regulation of cellular mechanisms.
ncRNAs are associated to higher eukaryotes complexity; accordingly, their dysfunction results in pathological phenotypes, including cancer.
To date, most research efforts have been mainly focused on how ncRNAs could modulate the expression of protein-coding genes in pathological phenotypes.
However, recent evidence has shown the existence of an unexpected interplay among ncRNAs that strongly influences cancer development and progression.
ncRNAs can interact with and regulate each other through various molecular mechanisms generating a complex network including different species of RNAs (e.g., mRNAs, miRNAs, lncRNAs, and circRNAs).
Such a hidden network of RNA-RNA competitive interactions pervades and modulates the physiological functioning of canonical protein-coding pathways involved in proliferation, differentiation, and metastasis in cancer.
Moreover, the pivotal role of ncRNAs as keystones of network structural integrity makes them very attractive and promising targets for innovative RNA-based therapeutics.
In this review we will discuss: (1) the current knowledge on complex crosstalk among ncRNAs, with a special focus on cancer; and (2) the main issues and criticisms concerning ncRNAs targeting in therapeutics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ragusa, Marco& Barbagallo, Cristina& Brex, Duilia& Caponnetto, Angela& Cirnigliaro, Matilde& Battaglia, Rosalia…[et al.]. 2017. Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1167060
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ragusa, Marco…[et al.]. Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer. International Journal of Genomics No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1167060
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ragusa, Marco& Barbagallo, Cristina& Brex, Duilia& Caponnetto, Angela& Cirnigliaro, Matilde& Battaglia, Rosalia…[et al.]. Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1167060
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167060
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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