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Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer
Joint Authors
Purrello, Michele
Ragusa, Marco
Barbagallo, Cristina
Brex, Duilia
Caponnetto, Angela
Cirnigliaro, Matilde
Battaglia, Rosalia
Barbagallo, Davide
Di Pietro, Cinzia
Source
International Journal of Genomics
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-24
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Over the past few years, noncoding RNAs (ncRNAs) have been extensively studied because of the significant biological roles that they play in regulation of cellular mechanisms.
ncRNAs are associated to higher eukaryotes complexity; accordingly, their dysfunction results in pathological phenotypes, including cancer.
To date, most research efforts have been mainly focused on how ncRNAs could modulate the expression of protein-coding genes in pathological phenotypes.
However, recent evidence has shown the existence of an unexpected interplay among ncRNAs that strongly influences cancer development and progression.
ncRNAs can interact with and regulate each other through various molecular mechanisms generating a complex network including different species of RNAs (e.g., mRNAs, miRNAs, lncRNAs, and circRNAs).
Such a hidden network of RNA-RNA competitive interactions pervades and modulates the physiological functioning of canonical protein-coding pathways involved in proliferation, differentiation, and metastasis in cancer.
Moreover, the pivotal role of ncRNAs as keystones of network structural integrity makes them very attractive and promising targets for innovative RNA-based therapeutics.
In this review we will discuss: (1) the current knowledge on complex crosstalk among ncRNAs, with a special focus on cancer; and (2) the main issues and criticisms concerning ncRNAs targeting in therapeutics.
American Psychological Association (APA)
Ragusa, Marco& Barbagallo, Cristina& Brex, Duilia& Caponnetto, Angela& Cirnigliaro, Matilde& Battaglia, Rosalia…[et al.]. 2017. Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer. International Journal of Genomics،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1167060
Modern Language Association (MLA)
Ragusa, Marco…[et al.]. Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer. International Journal of Genomics No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1167060
American Medical Association (AMA)
Ragusa, Marco& Barbagallo, Cristina& Brex, Duilia& Caponnetto, Angela& Cirnigliaro, Matilde& Battaglia, Rosalia…[et al.]. Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer. International Journal of Genomics. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1167060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167060