Histopathologic Parameters at Diagnosis as Early Predictors of Histologic Remission along the Course of Ulcerative Colitis
المؤلفون المشاركون
Yamamoto-Furusho, Jesús K.
Sánchez-Morales, Germán E.
Martínez-Benítez, Braulio
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-04
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Currently, the treatment goal in ulcerative colitis (UC) is to achieve clinical and endoscopic remission; nevertheless, histologic remission is a potential new treatment goal since it is associated with favorable long-term clinical outcome lower rates of hospitalization, complications, and colectomies.
Aim.
Evaluate clinical and histopathologic characteristics at diagnosis as potential predictors of histologic remission in patients with ulcerative colitis.
Methods.
This is a retrospective cohort study from 2007 to 2014, including 260 patients.
Clinical and demographic information and Mayo endoscopic and Riley histologic grade were obtained accordingly with the follow-up.
Histological evaluation was made for all 260 patients; fifty-six patients with histologic remission at the follow-up underwent separate evaluation of mucosal biopsy at the moment of diagnosis.
Univariate and multivariate analyses were applied to data from these 56 patients to identify histologic features at diagnosis associated with histologic remission during follow-up.
The odds ratio (OR) was determined as a measure for the strength of association.
A P value of less than 0.05 was taken as a level of significance.
Results.
The frequency of histologic remission according to the Riley index in our study group was 21.5%.
Factors associated with histologic remission were treatment with steroids (P=0.01, OR=0.38, CI 95%=0.16‐0.90), reduced mucin production (P=0.02, OR=0.23, CI 95%=0.06–0.86), and less than 10 eosinophils per high power field (P=0.001, OR=6.66, CI 95%=2.03–21.84).
Conclusion.
Factors that impair histologic remission in patients with ulcerative colitis were treatment with steroids and reduced mucin production; meanwhile, less than 10 eosinophils per high power showed a predictive value for histologic remission.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yamamoto-Furusho, Jesús K.& Martínez-Benítez, Braulio& Sánchez-Morales, Germán E.. 2020. Histopathologic Parameters at Diagnosis as Early Predictors of Histologic Remission along the Course of Ulcerative Colitis. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1167089
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yamamoto-Furusho, Jesús K.…[et al.]. Histopathologic Parameters at Diagnosis as Early Predictors of Histologic Remission along the Course of Ulcerative Colitis. Gastroenterology Research and Practice No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1167089
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yamamoto-Furusho, Jesús K.& Martínez-Benítez, Braulio& Sánchez-Morales, Germán E.. Histopathologic Parameters at Diagnosis as Early Predictors of Histologic Remission along the Course of Ulcerative Colitis. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1167089
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167089
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر