Histopathologic Parameters at Diagnosis as Early Predictors of Histologic Remission along the Course of Ulcerative Colitis

Joint Authors

Yamamoto-Furusho, Jesús K.
Sánchez-Morales, Germán E.
Martínez-Benítez, Braulio

Source

Gastroenterology Research and Practice

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-04

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Diseases

Abstract EN

Background.

Currently, the treatment goal in ulcerative colitis (UC) is to achieve clinical and endoscopic remission; nevertheless, histologic remission is a potential new treatment goal since it is associated with favorable long-term clinical outcome lower rates of hospitalization, complications, and colectomies.

Aim.

Evaluate clinical and histopathologic characteristics at diagnosis as potential predictors of histologic remission in patients with ulcerative colitis.

Methods.

This is a retrospective cohort study from 2007 to 2014, including 260 patients.

Clinical and demographic information and Mayo endoscopic and Riley histologic grade were obtained accordingly with the follow-up.

Histological evaluation was made for all 260 patients; fifty-six patients with histologic remission at the follow-up underwent separate evaluation of mucosal biopsy at the moment of diagnosis.

Univariate and multivariate analyses were applied to data from these 56 patients to identify histologic features at diagnosis associated with histologic remission during follow-up.

The odds ratio (OR) was determined as a measure for the strength of association.

A P value of less than 0.05 was taken as a level of significance.

Results.

The frequency of histologic remission according to the Riley index in our study group was 21.5%.

Factors associated with histologic remission were treatment with steroids (P=0.01, OR=0.38, CI 95%=0.16‐0.90), reduced mucin production (P=0.02, OR=0.23, CI 95%=0.06–0.86), and less than 10 eosinophils per high power field (P=0.001, OR=6.66, CI 95%=2.03–21.84).

Conclusion.

Factors that impair histologic remission in patients with ulcerative colitis were treatment with steroids and reduced mucin production; meanwhile, less than 10 eosinophils per high power showed a predictive value for histologic remission.

American Psychological Association (APA)

Yamamoto-Furusho, Jesús K.& Martínez-Benítez, Braulio& Sánchez-Morales, Germán E.. 2020. Histopathologic Parameters at Diagnosis as Early Predictors of Histologic Remission along the Course of Ulcerative Colitis. Gastroenterology Research and Practice،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1167089

Modern Language Association (MLA)

Yamamoto-Furusho, Jesús K.…[et al.]. Histopathologic Parameters at Diagnosis as Early Predictors of Histologic Remission along the Course of Ulcerative Colitis. Gastroenterology Research and Practice No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1167089

American Medical Association (AMA)

Yamamoto-Furusho, Jesús K.& Martínez-Benítez, Braulio& Sánchez-Morales, Germán E.. Histopathologic Parameters at Diagnosis as Early Predictors of Histologic Remission along the Course of Ulcerative Colitis. Gastroenterology Research and Practice. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1167089

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1167089