Ethanol-Induced Alterations of T Cells and Cytokines after Surgery in a Murine Infection Model
المؤلفون المشاركون
Spies, Claudia D.
von Haefen, Clarissa
Wernecke, Klaus-Dieter
Lanzke, Nadine
Menk, Mario
Sargsyan, Lilit
Scharf, Bianca
المصدر
International Journal of Inflammation
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-20
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
Interactions between alcohol, infection, and surgery and their effect on differentiation and functionality of T helper cells are not yet completely understood.
We hypothesized that alcohol and surgery disturb differentiation of T helper cells and contribute to an impaired immune response.
Methods.
Mice were treated with alcohol for two weeks.
Saline treatment served as control.
Clinical performance and weight were assessed.
On day 14, a median laparotomy was performed and animals were challenged with Klebsiella pneumoniae intranasally.
Bacterial load was determined in lungs and blood.
T helper cell subpopulations and the released cytokines were assessed in lungs, spleens, and plasma.
Key transcription factors of T cell differentiation were evaluated.
Results.
Alcohol significantly impaired clinical appearance and body weight of animals with postsurgical infection (p<0.05).
Bacterial load was significantly higher after alcohol treatment (p<0.05).
T helper cell subsets and released cytokine levels were significantly altered in lung, but not in spleen.
Expression of transcription factors of T helper cell lineage commitment did not translate into different counts of T helper cells.
Conclusions.
Alcohol and surgery lead to significant cellular and functional modulations of T helper cells during postsurgical infection.
These effects may contribute to an impaired immune response after surgery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lanzke, Nadine& Menk, Mario& von Haefen, Clarissa& Sargsyan, Lilit& Scharf, Bianca& Wernecke, Klaus-Dieter…[et al.]. 2017. Ethanol-Induced Alterations of T Cells and Cytokines after Surgery in a Murine Infection Model. International Journal of Inflammation،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1167420
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lanzke, Nadine…[et al.]. Ethanol-Induced Alterations of T Cells and Cytokines after Surgery in a Murine Infection Model. International Journal of Inflammation No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1167420
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lanzke, Nadine& Menk, Mario& von Haefen, Clarissa& Sargsyan, Lilit& Scharf, Bianca& Wernecke, Klaus-Dieter…[et al.]. Ethanol-Induced Alterations of T Cells and Cytokines after Surgery in a Murine Infection Model. International Journal of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1167420
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167420
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر