Transcriptional and Molecular Pathways Activated in Mesenteric Adipose Tissue and Intestinal Mucosa of Crohn’s Disease Patients
المؤلفون المشاركون
Milanski, Marciane
Ayrizono, Maria de Lourdes Setsuko
Camargo, Michel Gardere
Silva, Francesca A. R.
Leal, Raquel F.
Coope, Andressa
Pascoal, Lívia Bitencourt
Botezelli, José Diego
Planell, Núria
Portovedo, Mariana
Dias, Cilene Bicca
Fagundes, João José
المصدر
International Journal of Inflammation
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Crohn’s disease (CD) is a chronic inflammatory disorder, characterized by cytokine imbalance and transcription signaling pathways activation.
In addition, the increase of mesenteric adipose tissue (MAT) near the affected intestinal area is a hallmark of CD.
Therefore, we evaluated the transcription signaling pathways and cytokines expression in intestinal mucosa and MAT of active CD patients.
Ten patients with ileocecal CD and eight with noninflammatory diseases were studied.
The biopsies of intestinal mucosa and MAT were snap-frozen and protein expression was determined by immunoblotting.
RNA levels were measured by qPCR.
The pIkB/IkB ratio and TNFα level were significantly higher in intestinal mucosa of CD when compared to controls.
However, STAT1 expression was similar between intestinal mucosa of CD and controls.
Considering the MAT, the pIkB/IkB ratio was significantly lower and the anti-inflammatory cytokine IL10 was significantly higher in CD when compared to controls.
Finally, the protein content of pSTAT1 was higher in MAT of CD compared to controls.
These findings reinforce the predominance of the proinflammatory NF-kB pathway in CD intestinal mucosa.
For the first time, we showed the activation of STAT1 pathway in MAT of CD patients, which may help to understand the physiopathology of this immune mediated disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Coope, Andressa& Pascoal, Lívia Bitencourt& Silva, Francesca A. R.& Botezelli, José Diego& Ayrizono, Maria de Lourdes Setsuko& Milanski, Marciane…[et al.]. 2017. Transcriptional and Molecular Pathways Activated in Mesenteric Adipose Tissue and Intestinal Mucosa of Crohn’s Disease Patients. International Journal of Inflammation،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1167468
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Coope, Andressa…[et al.]. Transcriptional and Molecular Pathways Activated in Mesenteric Adipose Tissue and Intestinal Mucosa of Crohn’s Disease Patients. International Journal of Inflammation No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1167468
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Coope, Andressa& Pascoal, Lívia Bitencourt& Silva, Francesca A. R.& Botezelli, José Diego& Ayrizono, Maria de Lourdes Setsuko& Milanski, Marciane…[et al.]. Transcriptional and Molecular Pathways Activated in Mesenteric Adipose Tissue and Intestinal Mucosa of Crohn’s Disease Patients. International Journal of Inflammation. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1167468
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167468
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر