Neurodisability with Severe Restriction of Mobility Is Associated with Reduced Serum Creatinine Values

الملخص EN

Introduction.

We investigated whether reduced mobility is associated with a reduction in serum creatinine in otherwise well children with neurodisability.

Materials and Methods.

This was a record based retrospective study and creatinine levels of children in groups with Gross Motor Function Classification System (GMFCS) category 1, 2, or 3 (group I); GMFCS 4 or 5 (group II); and age matched controls (group III) were compared.

Results.

Creatinine values were significantly different (p=0.002) between patients with neurodisability (mean 32.0 (SD 9.3), n=88) compared to patients without (mean 36.5 SD (9.8), n=88).

There was no significant difference in creatinine levels (p=0.684) between group I (mean 35.6 (9.1), n=23) and group III (mean 36.5 (9.8), n=88).

A significantly lower creatinine level (p<0.001) was found in group II (mean 30.7 (9.1), n=65) compared to group III and group I compared to group II (p=0.034).

Creatinine levels were with a mean (SD) of 25.7 (4.1) micromol/l significantly lower in patients with GMFCS 4 or 5 who died (n=4) compared to survivors (31.1 (3.6)), (p=0.04, n=61).

Conclusions.

Children with neurodisability with severe mobility restriction had a significantly lower serum creatinine compared to controls with less severe or no neurodisability.

Death in severe neurodisability may be associated with lower creatinine levels.