Comprehensive Screening and Identification of Phillyrin Metabolites in Rats Based on UHPLC-Q-Exactive Mass Spectrometry Combined with Multi-Channel Data Mining
المؤلفون المشاركون
Ma, Beibei
Li, Jiameng
Lou, Tianyu
Liang, Yaoyue
Wang, Chenxiao
Li, Ruiji
Wang, Tingting
Liu, Jinhui
Guo, Yudong
Wang, Zhibin
Wang, Jing
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-24
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Phillyrin, a well-known bisepoxylignan, has been shown to have many critical pharmacological activities.
In this study, a novel strategy for the extensive acquisition and use of data was established based on UHPLC-Q-Exactive mass spectrometry to analyze and identify the in vivo metabolites of phillyrin and to elucidate the in vivo metabolic pathways of phillyrin.
Among them, the generation of data sets was mainly due to multichannel data mining methods, such as high extracted ion chromatogram (HEIC), diagnostic product ion (DPI), and neutral loss filtering (NLF).
A total of 60 metabolites (including the prototype compound) were identified in positive and negative ion modes based on intuitive and useful data such as the standard’s cleavage rule, accurate molecular mass, and chromatographic retention time.
The results showed that a series of biological reactions of phillyrin in vivo mainly included methylation, hydroxylation, hydrogenation, sulfonation, glucuronidation, demethylation, and dehydrogenation and their composite reactions.
In summary, this study not only comprehensively explained the in vivo metabolism of phillyrin, but also proposed an effective strategy to quickly analyze and identify the metabolites of natural pharmaceutical ingredients in nature.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Beibei& Li, Jiameng& Lou, Tianyu& Liang, Yaoyue& Wang, Chenxiao& Li, Ruiji…[et al.]. 2020. Comprehensive Screening and Identification of Phillyrin Metabolites in Rats Based on UHPLC-Q-Exactive Mass Spectrometry Combined with Multi-Channel Data Mining. International Journal of Analytical Chemistry،Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1167698
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Beibei…[et al.]. Comprehensive Screening and Identification of Phillyrin Metabolites in Rats Based on UHPLC-Q-Exactive Mass Spectrometry Combined with Multi-Channel Data Mining. International Journal of Analytical Chemistry No. 2020 (2020), pp.1-20.
https://search.emarefa.net/detail/BIM-1167698
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Beibei& Li, Jiameng& Lou, Tianyu& Liang, Yaoyue& Wang, Chenxiao& Li, Ruiji…[et al.]. Comprehensive Screening and Identification of Phillyrin Metabolites in Rats Based on UHPLC-Q-Exactive Mass Spectrometry Combined with Multi-Channel Data Mining. International Journal of Analytical Chemistry. 2020. Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1167698
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167698
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر