Systematic Analysis of the Whole-Body Tissue Distribution and Fatty Acid Compositions of Membrane Lipids in CD1 and NMRI Mice and Wistar Rats
المؤلفون المشاركون
Xu, Lina
Reichel, Andreas
Wang, Xueying
Schmitt, Maximilian V.
Ruan, Huabin
Jiao, Yupei
Wang, Yusong
Lienau, Philip
Liu, Xiaohui
Yang, Tao
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Understanding the tissue distribution of phospholipids and glycerolipids in animal models enables promoting the pharmacokinetic study of drugs and related PK predictions.
The measurement of lipid compositions in animal models, usually mice and rats, without a standardized approach hindered the accuracy of PBPK investigation.
In this work, high resolution mass spectrometry was applied to profile the tissue distribution of phospholipids and glycerolipids in 12 organs/tissues of mice and rats.
Using this method, not only the amounts of phospholipids and glycerolipids in each organ/tissue but also the fatty acid compositions were acquired.
In order to explore the interspecies specificity of lipid distribution in different organs/tissues, three animal species including CD1 mice, NMRI mice, and Wister rats were used in this systematic study.
Globally, more organ specificity was observed.
It was found that the brain is the organ containing the most abundant phosphatidylserine lipids (PSs) in all three animal models, leading to brain tissues having the most concentrated acidic phospholipids.
Diverse fatty acid compositions in each lipid class were clearly revealed.
Certain tissues/organs also had a specific selection of unique fatty acid compositions, for example, unreferenced FA(18 : 2) in the brain.
It turned out that the access of free fatty acids affects the incorporation of acyl chain in phospholipids and glycerolipids.
In the analysis, ether lipids were also profiled with the observation of dominant ePEs in brain tissues.
However, little interspecies difference was found for fatty acid constituents and tissues distribution of phospholipids and glycerolipids.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Lina& Schmitt, Maximilian V.& Ruan, Huabin& Jiao, Yupei& Wang, Xueying& Wang, Yusong…[et al.]. 2020. Systematic Analysis of the Whole-Body Tissue Distribution and Fatty Acid Compositions of Membrane Lipids in CD1 and NMRI Mice and Wistar Rats. International Journal of Analytical Chemistry،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1167738
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Lina…[et al.]. Systematic Analysis of the Whole-Body Tissue Distribution and Fatty Acid Compositions of Membrane Lipids in CD1 and NMRI Mice and Wistar Rats. International Journal of Analytical Chemistry No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1167738
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Lina& Schmitt, Maximilian V.& Ruan, Huabin& Jiao, Yupei& Wang, Xueying& Wang, Yusong…[et al.]. Systematic Analysis of the Whole-Body Tissue Distribution and Fatty Acid Compositions of Membrane Lipids in CD1 and NMRI Mice and Wistar Rats. International Journal of Analytical Chemistry. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1167738
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167738
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر