Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats
المؤلفون المشاركون
Ran, Jianmin
Liu, Yan
Zhu, Ping
Tan, Rongshao
Xu, Gang
Ma, Huixuan
Xu, Hailing
Song, Jun
Lao, Gancheng
المصدر
International Journal of Nephrology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aim.
In this study, we aimed to investigate the effects of febuxostat, a novel inhibitor of xanthine oxidase (XO), on renal damage in streptozotocin- (STZ-) induced diabetic rats.
Methods.
Diabetes was induced by the intraperitoneal injection of STZ in male Sprague-Dawley rats.
Sham-injected rats served as controls.
The control and diabetic rats were treated with and without febuxostat for 8 weeks, respectively.
Fasting blood and 24-h urine samples were collected every 4 weeks.
Rat livers were extracted for detecting gene expression, content, and bioactivity of XO.
Results.
Diabetic rats showed significantly increased serum uric acid (SUA), serum creatinine (SCr), and urea nitrogen (BUN) levels.
Daily urinary albumin (UAE), uric acid (UUA), and creatinine (UCr) excretion were also significantly increased in these rats.
In diabetic rats, at week 8, febuxostat decreased SUA by 18.9%, while UAA was increased by 52.0%.
However, UCr and urinary urea nitrogen (UUN) levels remained unchanged, while SCr and BUN levels decreased by >30% in these rats.
Although hepatic gene expression, content, and activity of XO increased significantly in diabetic rats, febuxostat only slightly decreased its content.
Conclusions.
Febuxostat significantly attenuated renal damage in STZ-induced diabetic rats in addition to exerting hypouricemic effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ran, Jianmin& Xu, Gang& Ma, Huixuan& Xu, Hailing& Liu, Yan& Tan, Rongshao…[et al.]. 2017. Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats. International Journal of Nephrology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1167803
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ran, Jianmin…[et al.]. Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats. International Journal of Nephrology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1167803
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ran, Jianmin& Xu, Gang& Ma, Huixuan& Xu, Hailing& Liu, Yan& Tan, Rongshao…[et al.]. Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats. International Journal of Nephrology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1167803
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167803
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر