Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats
Joint Authors
Ran, Jianmin
Liu, Yan
Zhu, Ping
Tan, Rongshao
Xu, Gang
Ma, Huixuan
Xu, Hailing
Song, Jun
Lao, Gancheng
Source
International Journal of Nephrology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aim.
In this study, we aimed to investigate the effects of febuxostat, a novel inhibitor of xanthine oxidase (XO), on renal damage in streptozotocin- (STZ-) induced diabetic rats.
Methods.
Diabetes was induced by the intraperitoneal injection of STZ in male Sprague-Dawley rats.
Sham-injected rats served as controls.
The control and diabetic rats were treated with and without febuxostat for 8 weeks, respectively.
Fasting blood and 24-h urine samples were collected every 4 weeks.
Rat livers were extracted for detecting gene expression, content, and bioactivity of XO.
Results.
Diabetic rats showed significantly increased serum uric acid (SUA), serum creatinine (SCr), and urea nitrogen (BUN) levels.
Daily urinary albumin (UAE), uric acid (UUA), and creatinine (UCr) excretion were also significantly increased in these rats.
In diabetic rats, at week 8, febuxostat decreased SUA by 18.9%, while UAA was increased by 52.0%.
However, UCr and urinary urea nitrogen (UUN) levels remained unchanged, while SCr and BUN levels decreased by >30% in these rats.
Although hepatic gene expression, content, and activity of XO increased significantly in diabetic rats, febuxostat only slightly decreased its content.
Conclusions.
Febuxostat significantly attenuated renal damage in STZ-induced diabetic rats in addition to exerting hypouricemic effect.
American Psychological Association (APA)
Ran, Jianmin& Xu, Gang& Ma, Huixuan& Xu, Hailing& Liu, Yan& Tan, Rongshao…[et al.]. 2017. Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats. International Journal of Nephrology،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1167803
Modern Language Association (MLA)
Ran, Jianmin…[et al.]. Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats. International Journal of Nephrology No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1167803
American Medical Association (AMA)
Ran, Jianmin& Xu, Gang& Ma, Huixuan& Xu, Hailing& Liu, Yan& Tan, Rongshao…[et al.]. Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats. International Journal of Nephrology. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1167803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167803