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A Validated Liquid Chromatographic Method for Berberine Analysis in Tissue and Application
المؤلفون المشاركون
Zhou, Neng
Liu, Dangmei
Bao, Xiaowang
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Simple and rapid high-performance liquid chromatography methods were developed for the determination of berberine (BB) in various rat tissues so as to evaluate a P-gp inhibitor, glycyrrhetinic acid (GA), on BB’s oral bioavailability.
Acetonitrile was used to extract BB from tissues and showed different extraction recoveries in diverse tissues.
The intra- and interday precision and accuracy were less than 10%.
Long-term stability, pre (post) -preparative stability, and freeze-thaw stability were evaluated, and the results showed it could meet the need of this study.
The proposed methods were subsequently applied to investigate the possible drug-drug interaction of GA and BB in vivo from the aspect of tissue distribution.
The results showed that no significant difference was found between the group of low dose and high dose at the same time point.
The tissue distributions show a saturated model, i.e., the content of BB in tissue tends to be constant while its dose is more than 200 mg/kg.
Besides, the contents of BB ranged from high to low according to the order of the liver, kidney, and spleen.
The BB content in the liver is especially high as compared to other tissues.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Neng& Liu, Dangmei& Bao, Xiaowang. 2020. A Validated Liquid Chromatographic Method for Berberine Analysis in Tissue and Application. International Journal of Analytical Chemistry،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1167807
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Neng…[et al.]. A Validated Liquid Chromatographic Method for Berberine Analysis in Tissue and Application. International Journal of Analytical Chemistry No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1167807
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Neng& Liu, Dangmei& Bao, Xiaowang. A Validated Liquid Chromatographic Method for Berberine Analysis in Tissue and Application. International Journal of Analytical Chemistry. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1167807
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167807
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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