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Analysis of T Cell Subsets in Adult PrimaryIdiopathic Minimal Change Disease: A Pilot Study
المؤلفون المشاركون
Salcido-Ochoa, Francisco
Hue, Susan Swee-Shan
Haase, Doreen
Choo, Jason Chon Jun
Li, Reiko Lixiang
Allen, John Carson
Iqbal, Jabed
Loh, Alwin Hwai Liang
Yusof, Nurhashikin
Rotzschke, Olaf
المصدر
International Journal of Nephrology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-15
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Aim.
To characterise infiltrating T cells in kidneys and circulating lymphocyte subsets of adult patients with primary/idiopathic minimal change disease.
Methods.
In a cohort of 9 adult patients with primary/idiopathic minimal change recruited consecutively at disease onset, we characterized (1) infiltrating immune cells in the kidneys using immunohistochemistry and (2) circulating lymphocyte subsets using flow cytometry.
As an exploratory analysis, association of the numbers and percentages of both kidney-infiltrating immune cells and the circulating lymphocyte subsets with kidney outcomes including deterioration of kidney function and proteinuria, as well as time to complete clinical remission up to 48 months of follow-up, was investigated.
Results.
In the recruited patients with primary/idiopathic minimal change disease, we observed (a) a dominance of infiltrating T helper 17 cells and cytotoxic cells, comprising cytotoxic T cells and natural killer cells, over Foxp3+ Treg cells in the renal interstitium; (b) an increase in the circulating total CD8+ T cells in peripheral blood; and (c) an association of some of these parameters with kidney function and proteinuria.
Conclusions.
In primary/idiopathic minimal change disease, a relative numerical dominance of effector over regulatory T cells can be observed in kidney tissue and peripheral blood.
However, larger confirmatory studies are necessary.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salcido-Ochoa, Francisco& Hue, Susan Swee-Shan& Haase, Doreen& Choo, Jason Chon Jun& Yusof, Nurhashikin& Li, Reiko Lixiang…[et al.]. 2017. Analysis of T Cell Subsets in Adult PrimaryIdiopathic Minimal Change Disease: A Pilot Study. International Journal of Nephrology،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1167811
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salcido-Ochoa, Francisco…[et al.]. Analysis of T Cell Subsets in Adult PrimaryIdiopathic Minimal Change Disease: A Pilot Study. International Journal of Nephrology No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1167811
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salcido-Ochoa, Francisco& Hue, Susan Swee-Shan& Haase, Doreen& Choo, Jason Chon Jun& Yusof, Nurhashikin& Li, Reiko Lixiang…[et al.]. Analysis of T Cell Subsets in Adult PrimaryIdiopathic Minimal Change Disease: A Pilot Study. International Journal of Nephrology. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1167811
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167811
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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