Analysis of T Cell Subsets in Adult PrimaryIdiopathic Minimal Change Disease: A Pilot Study
Joint Authors
Salcido-Ochoa, Francisco
Hue, Susan Swee-Shan
Haase, Doreen
Choo, Jason Chon Jun
Li, Reiko Lixiang
Allen, John Carson
Iqbal, Jabed
Loh, Alwin Hwai Liang
Yusof, Nurhashikin
Rotzschke, Olaf
Source
International Journal of Nephrology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Aim.
To characterise infiltrating T cells in kidneys and circulating lymphocyte subsets of adult patients with primary/idiopathic minimal change disease.
Methods.
In a cohort of 9 adult patients with primary/idiopathic minimal change recruited consecutively at disease onset, we characterized (1) infiltrating immune cells in the kidneys using immunohistochemistry and (2) circulating lymphocyte subsets using flow cytometry.
As an exploratory analysis, association of the numbers and percentages of both kidney-infiltrating immune cells and the circulating lymphocyte subsets with kidney outcomes including deterioration of kidney function and proteinuria, as well as time to complete clinical remission up to 48 months of follow-up, was investigated.
Results.
In the recruited patients with primary/idiopathic minimal change disease, we observed (a) a dominance of infiltrating T helper 17 cells and cytotoxic cells, comprising cytotoxic T cells and natural killer cells, over Foxp3+ Treg cells in the renal interstitium; (b) an increase in the circulating total CD8+ T cells in peripheral blood; and (c) an association of some of these parameters with kidney function and proteinuria.
Conclusions.
In primary/idiopathic minimal change disease, a relative numerical dominance of effector over regulatory T cells can be observed in kidney tissue and peripheral blood.
However, larger confirmatory studies are necessary.
American Psychological Association (APA)
Salcido-Ochoa, Francisco& Hue, Susan Swee-Shan& Haase, Doreen& Choo, Jason Chon Jun& Yusof, Nurhashikin& Li, Reiko Lixiang…[et al.]. 2017. Analysis of T Cell Subsets in Adult PrimaryIdiopathic Minimal Change Disease: A Pilot Study. International Journal of Nephrology،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1167811
Modern Language Association (MLA)
Salcido-Ochoa, Francisco…[et al.]. Analysis of T Cell Subsets in Adult PrimaryIdiopathic Minimal Change Disease: A Pilot Study. International Journal of Nephrology No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1167811
American Medical Association (AMA)
Salcido-Ochoa, Francisco& Hue, Susan Swee-Shan& Haase, Doreen& Choo, Jason Chon Jun& Yusof, Nurhashikin& Li, Reiko Lixiang…[et al.]. Analysis of T Cell Subsets in Adult PrimaryIdiopathic Minimal Change Disease: A Pilot Study. International Journal of Nephrology. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1167811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167811