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Apolipoprotein C-I Levels Are Associated with the Urinary ProteinUrinary Creatinine Ratio in Pediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: A Case Control Study
المؤلفون المشاركون
Odaka, Jun
Kanai, Takahiro
Ito, Takane
Saito, Takashi
Aoyagi, Jun
Betsui, Hiroyuki
Yamagata, Takanori
المصدر
International Journal of Nephrology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Humoral factors may cause idiopathic steroid-sensitive nephrotic syndrome (ISSNS).
In the present study, we analyzed serum proteins using mass spectrometry (MS) to identify proteins associated with the pathophysiology of pediatric ISSNS.
We collected serial serum samples from 33 children during each ISSNS phase; Phase A1 is the acute phase prior to steroid treatment (STx), Phase A2 represents the remission period with STx, and Phase A3 represents the remission period after completion of STx.
Children with normal urinalyses (Group B) and children with a nephrotic syndrome other than ISSNS (Group C) served as controls.
No significant differences in urinary protein/urinary creatinine (UP/UCr) ratios were observed between the children with phase A1 ISSNS and Group C.
We used surface-enhanced laser desorption/ionization time of flight MS for sample analysis.
Four ion peaks with a mass-to-charge ratio (m/z) of 6,444, 6,626, 8,695, and 8,915 were significantly elevated during ISSNS Phase A1 compared to Phase A2, Phase A3, and Group C.
The intensity of an m/z of 6,626 significantly correlated with the UP/UCr ratio and an m/z of 6,626 was identified as apolipoprotein C-I (Apo C-I).
Apo C-I levels correlate with the UP/UCr ratio in pediatric ISSNS.
Our findings provide new insights into the pathophysiology of ISSNS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Odaka, Jun& Kanai, Takahiro& Ito, Takane& Saito, Takashi& Aoyagi, Jun& Betsui, Hiroyuki…[et al.]. 2017. Apolipoprotein C-I Levels Are Associated with the Urinary ProteinUrinary Creatinine Ratio in Pediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: A Case Control Study. International Journal of Nephrology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1167834
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Odaka, Jun…[et al.]. Apolipoprotein C-I Levels Are Associated with the Urinary ProteinUrinary Creatinine Ratio in Pediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: A Case Control Study. International Journal of Nephrology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1167834
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Odaka, Jun& Kanai, Takahiro& Ito, Takane& Saito, Takashi& Aoyagi, Jun& Betsui, Hiroyuki…[et al.]. Apolipoprotein C-I Levels Are Associated with the Urinary ProteinUrinary Creatinine Ratio in Pediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: A Case Control Study. International Journal of Nephrology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1167834
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1167834
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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