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Apolipoprotein C-I Levels Are Associated with the Urinary ProteinUrinary Creatinine Ratio in Pediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: A Case Control Study
Joint Authors
Odaka, Jun
Kanai, Takahiro
Ito, Takane
Saito, Takashi
Aoyagi, Jun
Betsui, Hiroyuki
Yamagata, Takanori
Source
International Journal of Nephrology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Humoral factors may cause idiopathic steroid-sensitive nephrotic syndrome (ISSNS).
In the present study, we analyzed serum proteins using mass spectrometry (MS) to identify proteins associated with the pathophysiology of pediatric ISSNS.
We collected serial serum samples from 33 children during each ISSNS phase; Phase A1 is the acute phase prior to steroid treatment (STx), Phase A2 represents the remission period with STx, and Phase A3 represents the remission period after completion of STx.
Children with normal urinalyses (Group B) and children with a nephrotic syndrome other than ISSNS (Group C) served as controls.
No significant differences in urinary protein/urinary creatinine (UP/UCr) ratios were observed between the children with phase A1 ISSNS and Group C.
We used surface-enhanced laser desorption/ionization time of flight MS for sample analysis.
Four ion peaks with a mass-to-charge ratio (m/z) of 6,444, 6,626, 8,695, and 8,915 were significantly elevated during ISSNS Phase A1 compared to Phase A2, Phase A3, and Group C.
The intensity of an m/z of 6,626 significantly correlated with the UP/UCr ratio and an m/z of 6,626 was identified as apolipoprotein C-I (Apo C-I).
Apo C-I levels correlate with the UP/UCr ratio in pediatric ISSNS.
Our findings provide new insights into the pathophysiology of ISSNS.
American Psychological Association (APA)
Odaka, Jun& Kanai, Takahiro& Ito, Takane& Saito, Takashi& Aoyagi, Jun& Betsui, Hiroyuki…[et al.]. 2017. Apolipoprotein C-I Levels Are Associated with the Urinary ProteinUrinary Creatinine Ratio in Pediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: A Case Control Study. International Journal of Nephrology،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1167834
Modern Language Association (MLA)
Odaka, Jun…[et al.]. Apolipoprotein C-I Levels Are Associated with the Urinary ProteinUrinary Creatinine Ratio in Pediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: A Case Control Study. International Journal of Nephrology No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1167834
American Medical Association (AMA)
Odaka, Jun& Kanai, Takahiro& Ito, Takane& Saito, Takashi& Aoyagi, Jun& Betsui, Hiroyuki…[et al.]. Apolipoprotein C-I Levels Are Associated with the Urinary ProteinUrinary Creatinine Ratio in Pediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: A Case Control Study. International Journal of Nephrology. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1167834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1167834