Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss
المؤلفون المشاركون
Lyakhovich, Alex
Lleonart, Matilde E.
Graterol, D.
Mir, C.
Garcia-Vaquero, C.
Braña, I.
Pardo, A. N.
Rochera-Villach, M. I.
Lorente, J.
المصدر
International Journal of Otolaryngology
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-03
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Many drugs used for cancer chemotherapy produce reactive oxygen species, thus leading to various complications including nephrotoxicity, cardiotoxicity, and ototoxicity.
Objective.
We have provided a haplogroup analysis of a cohort of cancer patients treated with chemotherapy and compared factors associated with associated hearing loss.
Study Design and Methods.
This observational cohort study includes a pure-tone audiometry of the patients who underwent chemotherapeutic treatment.
Medical history, presence of risk factors for hearing loss, toxic habits, and association with haplogroups have been determined.
Results.
40% of patients developed hearing loss after administration of cisplatin, which was bilateral and symmetrical and of high frequencies.
The most frequent haplogroup was H with a slight overexpression of groups V and K and a low frequency of groups J and T.
No association of the haplogroup types with the hearing loss has been found; however age was revealed as an important determining factor.
Conclusions.
Ototoxicity caused by cisplatin is manifested as bilateral, symmetrical, and predominantly high frequency hearing loss.
Although we did not find a strong correlation of haplogroups with ototoxicity, our results revealed the existence of a risk group of elderly patients over 60, which are more susceptible to hearing loss induced by cisplatin, than young adults, regardless of preexisting hearing loss.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Graterol, D.& Mir, C.& Garcia-Vaquero, C.& Braña, I.& Pardo, A. N.& Rochera-Villach, M. I.…[et al.]. 2017. Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss. International Journal of Otolaryngology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1168005
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Graterol, D.…[et al.]. Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss. International Journal of Otolaryngology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1168005
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Graterol, D.& Mir, C.& Garcia-Vaquero, C.& Braña, I.& Pardo, A. N.& Rochera-Villach, M. I.…[et al.]. Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss. International Journal of Otolaryngology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1168005
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1168005
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر