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Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss
Joint Authors
Lyakhovich, Alex
Lleonart, Matilde E.
Graterol, D.
Mir, C.
Garcia-Vaquero, C.
Braña, I.
Pardo, A. N.
Rochera-Villach, M. I.
Lorente, J.
Source
International Journal of Otolaryngology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Many drugs used for cancer chemotherapy produce reactive oxygen species, thus leading to various complications including nephrotoxicity, cardiotoxicity, and ototoxicity.
Objective.
We have provided a haplogroup analysis of a cohort of cancer patients treated with chemotherapy and compared factors associated with associated hearing loss.
Study Design and Methods.
This observational cohort study includes a pure-tone audiometry of the patients who underwent chemotherapeutic treatment.
Medical history, presence of risk factors for hearing loss, toxic habits, and association with haplogroups have been determined.
Results.
40% of patients developed hearing loss after administration of cisplatin, which was bilateral and symmetrical and of high frequencies.
The most frequent haplogroup was H with a slight overexpression of groups V and K and a low frequency of groups J and T.
No association of the haplogroup types with the hearing loss has been found; however age was revealed as an important determining factor.
Conclusions.
Ototoxicity caused by cisplatin is manifested as bilateral, symmetrical, and predominantly high frequency hearing loss.
Although we did not find a strong correlation of haplogroups with ototoxicity, our results revealed the existence of a risk group of elderly patients over 60, which are more susceptible to hearing loss induced by cisplatin, than young adults, regardless of preexisting hearing loss.
American Psychological Association (APA)
Graterol, D.& Mir, C.& Garcia-Vaquero, C.& Braña, I.& Pardo, A. N.& Rochera-Villach, M. I.…[et al.]. 2017. Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss. International Journal of Otolaryngology،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1168005
Modern Language Association (MLA)
Graterol, D.…[et al.]. Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss. International Journal of Otolaryngology No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1168005
American Medical Association (AMA)
Graterol, D.& Mir, C.& Garcia-Vaquero, C.& Braña, I.& Pardo, A. N.& Rochera-Villach, M. I.…[et al.]. Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss. International Journal of Otolaryngology. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1168005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1168005