Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis

المؤلفون المشاركون

Lu, Gongbiao
Du, Lin
Lu, Jishou
Jin, Liuzhong

المصدر

International Journal of Polymer Science

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-07-14

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الفيزياء

الملخص EN

The pathogeny of osteoarthritis (OA) is very complicated and still is one of the difficulties in a treating procedure.

Here, we constructed nanoparticles using hyaluronan acid (HA) and astragalus polysaccharides (APS) for OA therapy.

We assessed OA biomarkers and IL-1β-induced matrix metalloproteinase (MMP) expressions.

Nanoparticles of 100 nm showed high drug loading of 28.6% (w/w) and extended drug release of 59% over 1 month.

Our results demonstrated that nano treatment significantly improved IL-1β-induced cell viability of chondrocytes.

Induction of MMP-9, MMP-13, and TNF-α was alleviated by nanoparticles.

Furthermore, nano elevated the expression of osteopontin (OPN) and attenuated inducible nitric oxide synthase (iNOS) protein.

Our data indicated the protective role of HA and APS-capsuled nanoparticles in OA treatment.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Lu, Gongbiao& Du, Lin& Lu, Jishou& Jin, Liuzhong. 2019. Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis. International Journal of Polymer Science،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1168263

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Lu, Gongbiao…[et al.]. Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis. International Journal of Polymer Science No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1168263

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Lu, Gongbiao& Du, Lin& Lu, Jishou& Jin, Liuzhong. Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis. International Journal of Polymer Science. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1168263

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1168263