Nanoparticles Containing Hyaluronan Acid and Astragalus Polysaccharides for Treating Osteoarthritis

Abstract EN

The pathogeny of osteoarthritis (OA) is very complicated and still is one of the difficulties in a treating procedure.

Here, we constructed nanoparticles using hyaluronan acid (HA) and astragalus polysaccharides (APS) for OA therapy.

We assessed OA biomarkers and IL-1β-induced matrix metalloproteinase (MMP) expressions.

Nanoparticles of 100 nm showed high drug loading of 28.6% (w/w) and extended drug release of 59% over 1 month.

Our results demonstrated that nano treatment significantly improved IL-1β-induced cell viability of chondrocytes.

Induction of MMP-9, MMP-13, and TNF-α was alleviated by nanoparticles.

Furthermore, nano elevated the expression of osteopontin (OPN) and attenuated inducible nitric oxide synthase (iNOS) protein.

Our data indicated the protective role of HA and APS-capsuled nanoparticles in OA treatment.