Effects of Dendrobium Officinale Polysaccharides on Brain Inflammation of Epileptic Rats
المؤلفون المشاركون
Zhang, Lin
Peng, Hua
Xu, Jin
Xu, Yixin
Yin, You
He, Bin
Zhuang, Jianhua
المصدر
International Journal of Polymer Science
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-05
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effects of Dendrobium officinale polysaccharides (DOPS) on the expression of inflammatory factors IL-1β and TNF-α and the MKP-1/MAPK signal pathway.
Methods.
PTZ-induced epileptic rat models were established.
The rats were randomly divided into four groups: the control group, the DOPS group, the model group, and the DOPS intervention group.
RT-PCR was used to measure the mRNA expression of IL-1β and TNF-α in the hippocampi of all groups; western blot was used to measure the protein expression of IL-1β and TNF-α and phosphorylation of ERK1/2, JNK, p38, and MKP-1 in the hippocampi of all groups at weeks 1, 2, 3, and 4 after modeling.
Results.
At weeks 1, 2, 3, and 4 after modeling, there were no significant differences between the control group and the DOPS group in the mRNA and protein expression of IL-1β and TNF-α and phosphorylation of ERK1/2, JNK, p38, and MKP-1 (all P>0.05); the mRNA and protein expression of IL-1β and TNF-α and phosphorylation of ERK1/2, JNK, and p38 were significantly increased, while the phosphorylation of MKP-1 was decreased in the model group compared with the control group.
The mRNA and protein expression of IL-1β and TNF-α and phosphorylation of ERK1/2, JNK, and p38 were significantly decreased, while the phosphorylation of MKP-1 was increased in the DOPS intervention group compared with the model group.
Conclusion.
DOPS can reduce PTZ-induced brain inflammation and seizures of epileptic rats by inhibiting IL-1β, TNF-α, and MAPK signal pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Lin& Peng, Hua& Xu, Jin& Xu, Yixin& Yin, You& He, Bin…[et al.]. 2019. Effects of Dendrobium Officinale Polysaccharides on Brain Inflammation of Epileptic Rats. International Journal of Polymer Science،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1168333
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Lin…[et al.]. Effects of Dendrobium Officinale Polysaccharides on Brain Inflammation of Epileptic Rats. International Journal of Polymer Science No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1168333
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Lin& Peng, Hua& Xu, Jin& Xu, Yixin& Yin, You& He, Bin…[et al.]. Effects of Dendrobium Officinale Polysaccharides on Brain Inflammation of Epileptic Rats. International Journal of Polymer Science. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1168333
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1168333
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر