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Effects of Dendrobium Officinale Polysaccharides on Brain Inflammation of Epileptic Rats
Joint Authors
Zhang, Lin
Peng, Hua
Xu, Jin
Xu, Yixin
Yin, You
He, Bin
Zhuang, Jianhua
Source
International Journal of Polymer Science
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To investigate the effects of Dendrobium officinale polysaccharides (DOPS) on the expression of inflammatory factors IL-1β and TNF-α and the MKP-1/MAPK signal pathway.
Methods.
PTZ-induced epileptic rat models were established.
The rats were randomly divided into four groups: the control group, the DOPS group, the model group, and the DOPS intervention group.
RT-PCR was used to measure the mRNA expression of IL-1β and TNF-α in the hippocampi of all groups; western blot was used to measure the protein expression of IL-1β and TNF-α and phosphorylation of ERK1/2, JNK, p38, and MKP-1 in the hippocampi of all groups at weeks 1, 2, 3, and 4 after modeling.
Results.
At weeks 1, 2, 3, and 4 after modeling, there were no significant differences between the control group and the DOPS group in the mRNA and protein expression of IL-1β and TNF-α and phosphorylation of ERK1/2, JNK, p38, and MKP-1 (all P>0.05); the mRNA and protein expression of IL-1β and TNF-α and phosphorylation of ERK1/2, JNK, and p38 were significantly increased, while the phosphorylation of MKP-1 was decreased in the model group compared with the control group.
The mRNA and protein expression of IL-1β and TNF-α and phosphorylation of ERK1/2, JNK, and p38 were significantly decreased, while the phosphorylation of MKP-1 was increased in the DOPS intervention group compared with the model group.
Conclusion.
DOPS can reduce PTZ-induced brain inflammation and seizures of epileptic rats by inhibiting IL-1β, TNF-α, and MAPK signal pathways.
American Psychological Association (APA)
Zhang, Lin& Peng, Hua& Xu, Jin& Xu, Yixin& Yin, You& He, Bin…[et al.]. 2019. Effects of Dendrobium Officinale Polysaccharides on Brain Inflammation of Epileptic Rats. International Journal of Polymer Science،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1168333
Modern Language Association (MLA)
Zhang, Lin…[et al.]. Effects of Dendrobium Officinale Polysaccharides on Brain Inflammation of Epileptic Rats. International Journal of Polymer Science No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1168333
American Medical Association (AMA)
Zhang, Lin& Peng, Hua& Xu, Jin& Xu, Yixin& Yin, You& He, Bin…[et al.]. Effects of Dendrobium Officinale Polysaccharides on Brain Inflammation of Epileptic Rats. International Journal of Polymer Science. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1168333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1168333