Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats
المؤلفون المشاركون
de Sales, Kelston Paulo Felice
Pinto, Bruno Araújo Serra
Ribeiro, Nathalee Liberal Xavier
Melo, Thamys Marinho
Galvão-Moreira, Leonardo Victor
de Brito Filho, Sebastião Barreto
Nigri, Flávio
المصدر
International Journal of Vascular Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Reperfusion syndrome after carotid endarterectomy is a complication associated with cerebrovascular self-regulation in a chronically hypoperfused cerebral hemisphere, leading to severe neurological damage.
Vitamin C is an important antioxidant in brain metabolism that has shown some neuroprotective actions.
Objective.
To investigate the potential effects of vitamin C on cerebral reperfusion in comparison with placebo (saline) in rats.
Methods.
Male Wistar rats were divided into 3 groups: (i) Sham (n=4), animals exposed to carotid arteries dissection without clamping; (ii) Control (n=4), animals that received an intraperitoneal injection of 0.9% saline solution (0.1 mL/kg) and underwent carotid arteries dissection with temporary clamping; (iii) Vitamin C (n=4), animals that received an intraperitoneal injection of vitamin C (750 mg/kg) and underwent carotid arteries dissection with temporary clamping.
Behavioral assessment was then performed in all groups, which included the open field, Morris water maze and rotarod tests.
Levels of malondialdehyde (MDA) in the hippocampus and striatum were measured using a fluorometric assay.
Results.
Rats treated with vitamin C presented with a similar behavior as compared to the Sham group in all the three tests (p>0.05), but it was significantly different from controls (p<0.05).
Vitamin C was also found to reduce MDA levels in both hippocampus and striatum when compared to placebo (p<0.05).
Conclusion.
In the present study, vitamin C was associated with behavioral and motor preservation as well as decreased cerebral MDA levels after induced cerebral ischemia in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Sales, Kelston Paulo Felice& Pinto, Bruno Araújo Serra& Ribeiro, Nathalee Liberal Xavier& Melo, Thamys Marinho& Galvão-Moreira, Leonardo Victor& de Brito Filho, Sebastião Barreto…[et al.]. 2019. Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats. International Journal of Vascular Medicine،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1168701
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Sales, Kelston Paulo Felice…[et al.]. Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats. International Journal of Vascular Medicine No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1168701
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Sales, Kelston Paulo Felice& Pinto, Bruno Araújo Serra& Ribeiro, Nathalee Liberal Xavier& Melo, Thamys Marinho& Galvão-Moreira, Leonardo Victor& de Brito Filho, Sebastião Barreto…[et al.]. Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats. International Journal of Vascular Medicine. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1168701
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1168701
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر