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Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats
Joint Authors
de Sales, Kelston Paulo Felice
Pinto, Bruno Araújo Serra
Ribeiro, Nathalee Liberal Xavier
Melo, Thamys Marinho
Galvão-Moreira, Leonardo Victor
de Brito Filho, Sebastião Barreto
Nigri, Flávio
Source
International Journal of Vascular Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Reperfusion syndrome after carotid endarterectomy is a complication associated with cerebrovascular self-regulation in a chronically hypoperfused cerebral hemisphere, leading to severe neurological damage.
Vitamin C is an important antioxidant in brain metabolism that has shown some neuroprotective actions.
Objective.
To investigate the potential effects of vitamin C on cerebral reperfusion in comparison with placebo (saline) in rats.
Methods.
Male Wistar rats were divided into 3 groups: (i) Sham (n=4), animals exposed to carotid arteries dissection without clamping; (ii) Control (n=4), animals that received an intraperitoneal injection of 0.9% saline solution (0.1 mL/kg) and underwent carotid arteries dissection with temporary clamping; (iii) Vitamin C (n=4), animals that received an intraperitoneal injection of vitamin C (750 mg/kg) and underwent carotid arteries dissection with temporary clamping.
Behavioral assessment was then performed in all groups, which included the open field, Morris water maze and rotarod tests.
Levels of malondialdehyde (MDA) in the hippocampus and striatum were measured using a fluorometric assay.
Results.
Rats treated with vitamin C presented with a similar behavior as compared to the Sham group in all the three tests (p>0.05), but it was significantly different from controls (p<0.05).
Vitamin C was also found to reduce MDA levels in both hippocampus and striatum when compared to placebo (p<0.05).
Conclusion.
In the present study, vitamin C was associated with behavioral and motor preservation as well as decreased cerebral MDA levels after induced cerebral ischemia in rats.
American Psychological Association (APA)
de Sales, Kelston Paulo Felice& Pinto, Bruno Araújo Serra& Ribeiro, Nathalee Liberal Xavier& Melo, Thamys Marinho& Galvão-Moreira, Leonardo Victor& de Brito Filho, Sebastião Barreto…[et al.]. 2019. Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats. International Journal of Vascular Medicine،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1168701
Modern Language Association (MLA)
de Sales, Kelston Paulo Felice…[et al.]. Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats. International Journal of Vascular Medicine No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1168701
American Medical Association (AMA)
de Sales, Kelston Paulo Felice& Pinto, Bruno Araújo Serra& Ribeiro, Nathalee Liberal Xavier& Melo, Thamys Marinho& Galvão-Moreira, Leonardo Victor& de Brito Filho, Sebastião Barreto…[et al.]. Effects of Vitamin C on the Prevention of Ischemia-Reperfusion Brain Injury: Experimental Study in Rats. International Journal of Vascular Medicine. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1168701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1168701