Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6
المؤلفون المشاركون
Ansah, Charles
Obiri, David D.
Osafo, Newman
Antwi, Aaron O.
Duduyemi, Babatunde M.
Owusu, George
Ainooson, George K.
المصدر
International Journal of Chronic Diseases
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-06
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Ulcerative colitis (UC) is a recurrent inflammatory bowel disease (IBD) that causes long-lasting inflammation on the innermost lining of the colon and rectum.
Leaf decoctions of Cordia vignei have been used in traditional medicine either alone or in combination with other plant preparations to treat the disease.
Aim.
In this study, we investigated the effect of hydroethanolic extract of Cordia vignei leaves (CVE) on acetic acid-induced UC in rats.
Method.
Male Sprague Dawley rats received oral treatment of either saline (10 ml/kg), sulfasalazine (500 mg/kg), or CVE (30-300 mg/kg) daily for 7 days.
On day 4, colitis was induced by a single intrarectal administration of 500 μl of acetic acid (4% v/v).
Rats were sacrificed on day 8 and colons were collected for histopathological examination.
Blood was also collected for haematological assessment.
Results.
CVE significantly (P < 0.05) prevented colonic ulceration and reduced the inflammatory score.
Serum levels of TNF-α and IL-6 were significantly reduced.
Depletion of superoxide dismutase (SOD) and catalase (CAT) activities by acetic acid was significantly inhibited while lipid peroxidation indexed as malondialdehyde (MDA) level in the colon was reduced.
However, loss of body weight was not significantly affected by treatment with CVE.
Conclusion.
This data suggest that CVE has a potential antiulcerative effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Owusu, George& Obiri, David D.& Ainooson, George K.& Osafo, Newman& Antwi, Aaron O.& Duduyemi, Babatunde M.…[et al.]. 2020. Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6. International Journal of Chronic Diseases،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1169334
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Owusu, George…[et al.]. Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6. International Journal of Chronic Diseases No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1169334
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Owusu, George& Obiri, David D.& Ainooson, George K.& Osafo, Newman& Antwi, Aaron O.& Duduyemi, Babatunde M.…[et al.]. Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6. International Journal of Chronic Diseases. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1169334
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1169334
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر