Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6
Joint Authors
Ansah, Charles
Obiri, David D.
Osafo, Newman
Antwi, Aaron O.
Duduyemi, Babatunde M.
Owusu, George
Ainooson, George K.
Source
International Journal of Chronic Diseases
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-06
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Ulcerative colitis (UC) is a recurrent inflammatory bowel disease (IBD) that causes long-lasting inflammation on the innermost lining of the colon and rectum.
Leaf decoctions of Cordia vignei have been used in traditional medicine either alone or in combination with other plant preparations to treat the disease.
Aim.
In this study, we investigated the effect of hydroethanolic extract of Cordia vignei leaves (CVE) on acetic acid-induced UC in rats.
Method.
Male Sprague Dawley rats received oral treatment of either saline (10 ml/kg), sulfasalazine (500 mg/kg), or CVE (30-300 mg/kg) daily for 7 days.
On day 4, colitis was induced by a single intrarectal administration of 500 μl of acetic acid (4% v/v).
Rats were sacrificed on day 8 and colons were collected for histopathological examination.
Blood was also collected for haematological assessment.
Results.
CVE significantly (P < 0.05) prevented colonic ulceration and reduced the inflammatory score.
Serum levels of TNF-α and IL-6 were significantly reduced.
Depletion of superoxide dismutase (SOD) and catalase (CAT) activities by acetic acid was significantly inhibited while lipid peroxidation indexed as malondialdehyde (MDA) level in the colon was reduced.
However, loss of body weight was not significantly affected by treatment with CVE.
Conclusion.
This data suggest that CVE has a potential antiulcerative effect.
American Psychological Association (APA)
Owusu, George& Obiri, David D.& Ainooson, George K.& Osafo, Newman& Antwi, Aaron O.& Duduyemi, Babatunde M.…[et al.]. 2020. Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6. International Journal of Chronic Diseases،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1169334
Modern Language Association (MLA)
Owusu, George…[et al.]. Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6. International Journal of Chronic Diseases No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1169334
American Medical Association (AMA)
Owusu, George& Obiri, David D.& Ainooson, George K.& Osafo, Newman& Antwi, Aaron O.& Duduyemi, Babatunde M.…[et al.]. Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6. International Journal of Chronic Diseases. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1169334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169334