PCR detection of the soluble receptor for the advanced glycosylated end products (SRAGE) in the gingival tissues of diabetic patients affected by chronic periodontitis
المؤلف
Ibrahim, Muhammad Abd al-Munim
المصدر
العدد
المجلد 25، العدد 1 (31 يناير/كانون الثاني 2009)، ص ص. 69-82، 14ص.
الناشر
جامعة القاهرة كلية طب الفم و الأسنان
تاريخ النشر
2009-01-31
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : There is a two way relationship between diabetes and periodontitis.
AGE accumulates in the tissues by aging or due to hyperglycemic state.
AGE affect the periodontal tissues through binding with RAGE specific receptor and stimulate a cascade of inflammatory and immune reactions leading to tissue destruction.
There is a soluble form of RAGE called sRAGE present normally in the body and acts as a competitive inhibitor to RAGE by binding to its ligands and prevent tissue destruction.
Aim : Was to assess the frequency of Expression of mRNA of the soluble Receptor of Advanced Glycosylated End products (sRAGE) in gingival tissues of type 2 diabetic patients affected by chronic periodontitis by the use of PCR.
Method : -The subjects of the study were 36 patients grouped into three groups G I systemically free affected by chronic periodontitis as a control group (n = 12), G II well controlled diabetic subjects affected by type 2 diabetes and chronic periodontitis (n = 12) and G III poorly controlled diabetic patients affected by type 2 diabetes and chronic periodontitis (n = 12).
Gingival biopsies were collected during surgical periodontal therapy of the subjects and stored at (- 70) to be used for mRNA extraction and subsequent RT–PCR detection of the sRAGE.
Results : The present study showed that the expression of sRAGE was increased in well controlled diabetics and in non diabetics with less scores and measurements of clinical parameters.
sRAGE mRNA in the present study was negatively expressed in 83.33 % of the poorly controlled diabetics and in patients presented with more periodontal tissue destruction.
Conclusion : sRAGE was reported to be associated with non diabetic states and with glycemic control of type 2 diabetes and inversely associated with components of the metabolic syndrome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ibrahim, Muhammad Abd al-Munim. 2009. PCR detection of the soluble receptor for the advanced glycosylated end products (SRAGE) in the gingival tissues of diabetic patients affected by chronic periodontitis. Cairo Dental Journal،Vol. 25, no. 1, pp.69-82.
https://search.emarefa.net/detail/BIM-116940
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ibrahim, Muhammad Abd al-Munim. PCR detection of the soluble receptor for the advanced glycosylated end products (SRAGE) in the gingival tissues of diabetic patients affected by chronic periodontitis. Cairo Dental Journal (Apr. 2009), pp.69-82.
https://search.emarefa.net/detail/BIM-116940
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ibrahim, Muhammad Abd al-Munim. PCR detection of the soluble receptor for the advanced glycosylated end products (SRAGE) in the gingival tissues of diabetic patients affected by chronic periodontitis. Cairo Dental Journal. 2009. Vol. 25, no. 1, pp.69-82.
https://search.emarefa.net/detail/BIM-116940
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 79-82.
رقم السجل
BIM-116940
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر