Practical Consequences Resulting from the Analysis of a 21-Multigene Array in the Interdisciplinary Conference of a Breast Cancer Center
المؤلفون المشاركون
Voelker, Hans-Ullrich
Strehl, Annette
Frey, L.
Weigel, Michael
المصدر
International Journal of Breast Cancer
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
During the multidisciplinary planning of postoperative therapy after breast cancer, borderline cases can arise with no clear rationale for or against adjuvant chemotherapy.
In 50 hormone- receptor-positive, Her2neu-negative carcinomas of the breast with no or only minimal lymph node involvement (max.
pT1a) we initiated an Oncotype DX® multigene assay in addition to the evaluation of usual parameters.
In the oncology conference a vote for or against chemotherapy was taken on the basis of the conventional criteria for decision-making before the test results were available.
The final recommendation was made after the multigene test.
In 32 breast carcinomas (64%) a low recurrence score could be documented, while 26 (32%) showed an intermediate RS and 3 (6%) showed a high RS.
In most cases the result of the test could validate the choice of therapy established using conventional criteria.
In 5 cases the initial recommendation for adjuvant therapy was revised, and in 3 cases chemotherapy was secondarily recommended after evaluation of the test results.
Conversely, in some cases a low or intermediate risk constellation did not argue against a recommendation for adjuvant chemotherapy.
Altogether, the results of our study do not indicate that a multigene assay should be used as a routine diagnostic tool.
Instead a thorough compilation and careful analysis of conventional parameters for therapeutic decision-making should take precedence, with special emphasis on histopathological and immunohistochemical results.
In selected cases, however, a multigene assay can be a useful tool in the deliberation for or against a therapeutic pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Voelker, Hans-Ullrich& Frey, L.& Strehl, Annette& Weigel, Michael. 2018. Practical Consequences Resulting from the Analysis of a 21-Multigene Array in the Interdisciplinary Conference of a Breast Cancer Center. International Journal of Breast Cancer،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1169428
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Voelker, Hans-Ullrich…[et al.]. Practical Consequences Resulting from the Analysis of a 21-Multigene Array in the Interdisciplinary Conference of a Breast Cancer Center. International Journal of Breast Cancer No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1169428
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Voelker, Hans-Ullrich& Frey, L.& Strehl, Annette& Weigel, Michael. Practical Consequences Resulting from the Analysis of a 21-Multigene Array in the Interdisciplinary Conference of a Breast Cancer Center. International Journal of Breast Cancer. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1169428
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1169428
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر