Practical Consequences Resulting from the Analysis of a 21-Multigene Array in the Interdisciplinary Conference of a Breast Cancer Center
Joint Authors
Voelker, Hans-Ullrich
Strehl, Annette
Frey, L.
Weigel, Michael
Source
International Journal of Breast Cancer
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
During the multidisciplinary planning of postoperative therapy after breast cancer, borderline cases can arise with no clear rationale for or against adjuvant chemotherapy.
In 50 hormone- receptor-positive, Her2neu-negative carcinomas of the breast with no or only minimal lymph node involvement (max.
pT1a) we initiated an Oncotype DX® multigene assay in addition to the evaluation of usual parameters.
In the oncology conference a vote for or against chemotherapy was taken on the basis of the conventional criteria for decision-making before the test results were available.
The final recommendation was made after the multigene test.
In 32 breast carcinomas (64%) a low recurrence score could be documented, while 26 (32%) showed an intermediate RS and 3 (6%) showed a high RS.
In most cases the result of the test could validate the choice of therapy established using conventional criteria.
In 5 cases the initial recommendation for adjuvant therapy was revised, and in 3 cases chemotherapy was secondarily recommended after evaluation of the test results.
Conversely, in some cases a low or intermediate risk constellation did not argue against a recommendation for adjuvant chemotherapy.
Altogether, the results of our study do not indicate that a multigene assay should be used as a routine diagnostic tool.
Instead a thorough compilation and careful analysis of conventional parameters for therapeutic decision-making should take precedence, with special emphasis on histopathological and immunohistochemical results.
In selected cases, however, a multigene assay can be a useful tool in the deliberation for or against a therapeutic pathway.
American Psychological Association (APA)
Voelker, Hans-Ullrich& Frey, L.& Strehl, Annette& Weigel, Michael. 2018. Practical Consequences Resulting from the Analysis of a 21-Multigene Array in the Interdisciplinary Conference of a Breast Cancer Center. International Journal of Breast Cancer،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1169428
Modern Language Association (MLA)
Voelker, Hans-Ullrich…[et al.]. Practical Consequences Resulting from the Analysis of a 21-Multigene Array in the Interdisciplinary Conference of a Breast Cancer Center. International Journal of Breast Cancer No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1169428
American Medical Association (AMA)
Voelker, Hans-Ullrich& Frey, L.& Strehl, Annette& Weigel, Michael. Practical Consequences Resulting from the Analysis of a 21-Multigene Array in the Interdisciplinary Conference of a Breast Cancer Center. International Journal of Breast Cancer. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1169428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1169428